Journalartikel

Jahr der Veröffentlichung: 2016

Seiten: 219-243

Zeitschrift: Advances in Virus Research

Bandnummer: 96

ISSN: 0065-3527

Open Access Status: Green

DOI Link: https://doi.org/10.1016/bs.aivir.2016.08.006

Verlag: Academic Press Inc Ltd

Serientitel: Advances in Virus Research

Abstract: 

Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) are the most severe coronavirus (CoV)-associated diseases in humans. The causative agents, SARS-CoV and MERS-CoV, are of zoonotic origin but may be transmitted to humans, causing severe and often fatal respiratory disease in their new host. The two coronaviruses are thought to encode an unusually large number of factors that allow them to thrive and replicate in the presence of efficient host defense mechanisms, especially the antiviral interferon system. Here, we review the recent progress in our understanding of the strategies that highly pathogenic coronaviruses employ to escape, dampen, or block the antiviral interferon response in human cells.

Harvard-Zitierstil: Kindler, E., Thiel, V. and Weber, F. (2016) Interaction of SARS and MERS Coronaviruses with the Antiviral Interferon Response, Advances in Virus Research, 96, pp. 219-243. https://doi.org/10.1016/bs.aivir.2016.08.006

APA-Zitierstil: Kindler, E., Thiel, V., & Weber, F. (2016). Interaction of SARS and MERS Coronaviruses with the Antiviral Interferon Response. Advances in Virus Research. 96, 219-243. https://doi.org/10.1016/bs.aivir.2016.08.006