Journal article

Publication year: 2015

Pages: 38-41

Journal: Cytokine

Volume number: 76

Issue number: 1

ISSN: 1043-4666

eISSN: 1096-0023

DOI Link: https://doi.org/10.1016/j.cyto.2015.07.002

Publisher: Elsevier

Abstract: 

Retinoic-acid inducible gene I (RIG-I) is a major pattern recognition receptor of the innate immune system. RIG-I is a cytoplasmic RNA helicase that is able to bind virus-specific RNA structures. Activated RIG-I switches into a conformation that locks the ligand RNA and signals via the MAVS-IRF-3 axis, resulting in the upregulation of antiviral interferons. Recent evidence suggests that the binding of RIG-I to regulatory RNA structures of two major human pathogens, influenza A virus and hepatitis B virus, can inhibit viral replication independent of the subsequent signal transduction. Thus, RIG-I rides a two-pronged attack, with an early-hitting, direct inhibition via occupancy of viral regulatory RNA structures, and a delayed response via signaling and induction of interferons. (C) 2015 Elsevier Ltd. All rights reserved.

Harvard Citation style: Weber, F. (2015) The catcher in the RIG-I, Cytokine, 76(1), pp. 38-41. https://doi.org/10.1016/j.cyto.2015.07.002

APA Citation style: Weber, F. (2015). The catcher in the RIG-I. Cytokine. 76(1), 38-41. https://doi.org/10.1016/j.cyto.2015.07.002