Journal article

Publication year: 2014

Pages: 621-628

Journal: Cytokine & Growth Factor Reviews

Volume number: 25

Issue number: 5

ISSN: 1359-6101

eISSN: 1879-0305

DOI Link: https://doi.org/10.1016/j.cytogfr.2014.05.004

Publisher: Elsevier

Abstract: 

Negative strand RNA viruses with a nonsegmented genome (ns-NSVs) or a segmented genome (s-NSVs) are an important source of human and animal diseases. Survival of the host from those infections is critically dependent on rapidly reacting innate immune responses. Two cytoplasmic RNA helicases, RIG-I and MDA5 (collectively termed RIG-I-like receptors, RLRs), are essential for recognizing virus-specific RNA structures to initiate a signalling cascade, resulting in the production of the antiviral type I interferons. Here, we will review the current knowledge and views on RLR agonists, RLR signalling, and the wide variety of countermeasures ns-NSVs and s-NSVs have evolved. Specific aspects include the consequences of genome segmentation for RLR activation and a discussion on the physiological ligands of RLRs.

Harvard Citation style: Weber, M. and Weber, F. (2014) RIG-I-like receptors and negative-strand RNA viruses: RLRly bird catches some worms, Cytokine & Growth Factor Reviews, 25(5), pp. 621-628. https://doi.org/10.1016/j.cytogfr.2014.05.004

APA Citation style: Weber, M., & Weber, F. (2014). RIG-I-like receptors and negative-strand RNA viruses: RLRly bird catches some worms. Cytokine & Growth Factor Reviews. 25(5), 621-628. https://doi.org/10.1016/j.cytogfr.2014.05.004