Journal article

Publication year: 2020

Pages: 712-716

Journal: Journal of General Virology

Volume number: 101

Issue number: 7

ISSN: 0022-1317

eISSN: 1465-2099

Open access status: Green

DOI Link: https://doi.org/10.1099/jgv.0.001347

Publisher: Microbiology Society

Abstract: 

The non-structural protein NSs is the main virulence factor of Rift Valley fever virus, a major zoonotic pathogen in Africa. NSs forms large aggregates in the nucleus and impairs induction of the antiviral type I IFN system by several mechanisms, including degradation of subunit p62 of the general RNA polymerase II transcription factor TFIIH. Here, we show that depletion of the nuclear pore protein Nup98 affects the nuclear import of NSs. Nonetheless, NSs was still able to degrade TFIIH-p62 under these conditions. Depletion of Nup98, however, had a negative effect on Rift Valley fever virus multiplication. Our data thus indicate that NSs utilizes Nup98 for import into the nucleus, but also plays a general role in the viral replication cycle.

Harvard Citation style: Lau, S. and Weber, F. (2020) Nuclear pore protein Nup98 is involved in replication of Rift Valley fever virus and nuclear import of virulence factor NSs, Journal of General Virology, 101(7), pp. 712-716. https://doi.org/10.1099/jgv.0.001347

APA Citation style: Lau, S., & Weber, F. (2020). Nuclear pore protein Nup98 is involved in replication of Rift Valley fever virus and nuclear import of virulence factor NSs. Journal of General Virology. 101(7), 712-716. https://doi.org/10.1099/jgv.0.001347