Journal article

Publication year: 2022

Journal: PNAS Nexus

Volume number: 1

Issue number: 2

eISSN: 2752-6542

Open access status: Gold

DOI Link: https://doi.org/10.1093/pnasnexus/pgac067

Publisher: Oxford University Press

Abstract: 

The new variant of concern (VOC) of SARS-CoV-2, Omicron (B.1.1.529), is genetically very different from other VOCs. We compared Omicron with the preceding VOC Delta (B.1.617.2) and the wildtype (wt) strain (B.1) with respect to their interactions with the antiviral interferon (IFN-alpha/beta) response in infected cells. Our data indicate that IFN induction by Omicron is low and comparable to the wt, whereas Delta showed an increased IFN induction. However, Omicron exceeded both the wt and the Delta strain with respect to the ability to withstand the antiviral state imposed by IFN-alpha.

Harvard Citation style: Shalamova, L., Felgenhauer, U., Wilhelm, J., Schaubmar, A., Büttner, K., Schoen, A., et al. (2022) Omicron variant of SARS-CoV-2 exhibits an increased resilience to the antiviral type I interferon response, PNAS Nexus, 1(2), Article pgac067. https://doi.org/10.1093/pnasnexus/pgac067

APA Citation style: Shalamova, L., Felgenhauer, U., Wilhelm, J., Schaubmar, A., Büttner, K., Schoen, A., Widera, M., Ciesek, S., & Weber, F. (2022). Omicron variant of SARS-CoV-2 exhibits an increased resilience to the antiviral type I interferon response. PNAS Nexus. 1(2), Article pgac067. https://doi.org/10.1093/pnasnexus/pgac067