Journal article
Authors list: Batatinha, HAP; Diniz, TA; de Souza Teixeira, AA; Krüger, K; Rosa-Neto, JC
Publication year: 2019
Pages: 14883-14895
Journal: Journal of Cellular Physiology
Volume number: 234
Issue number: 9
ISSN: 0021-9541
eISSN: 1097-4652
DOI Link: https://doi.org/10.1002/jcp.28318
Publisher: Wiley
Aging is one of the risk factors for the development of low-grade inflammation morbidities, such as several types of cancer and neurodegenerative diseases, due to changes in the metabolism, hormonal secretion, and immunosenescence. The senescence of the immune system leads to improper control of infections and tissue damage increasing age-related diseases. One of the mechanisms that maintain cellular homeostasis is autophagy, a cell-survival mechanism, and it has been proposed as one of the most powerful antiaging therapies. Regular exercise can reestablish autophagy, probably through AMP-activated protein kinase activation, and help in reducing the age-related senescence diseases. Therefore, in this study, we discuss the effects of exercise training in immunosenescence and autophagy, preventing the two main age-related disease, cancer and neurodegeneration.
Abstract:
Citation Styles
Harvard Citation style: Batatinha, H., Diniz, T., de Souza Teixeira, A., Krüger, K. and Rosa-Neto, J. (2019) Regulation of autophagy as a therapy for immunosenescence-driven cancer and neurodegenerative diseases: The role of exercise, Journal of Cellular Physiology, 234(9), pp. 14883-14895. https://doi.org/10.1002/jcp.28318
APA Citation style: Batatinha, H., Diniz, T., de Souza Teixeira, A., Krüger, K., & Rosa-Neto, J. (2019). Regulation of autophagy as a therapy for immunosenescence-driven cancer and neurodegenerative diseases: The role of exercise. Journal of Cellular Physiology. 234(9), 14883-14895. https://doi.org/10.1002/jcp.28318