Journal article

Regulation of autophagy as a therapy for immunosenescence-driven cancer and neurodegenerative diseases: The role of exercise


Authors listBatatinha, HAP; Diniz, TA; de Souza Teixeira, AA; Krüger, K; Rosa-Neto, JC

Publication year2019

Pages14883-14895

JournalJournal of Cellular Physiology

Volume number234

Issue number9

ISSN0021-9541

eISSN1097-4652

DOI Linkhttps://doi.org/10.1002/jcp.28318

PublisherWiley


Abstract

Aging is one of the risk factors for the development of low-grade inflammation morbidities, such as several types of cancer and neurodegenerative diseases, due to changes in the metabolism, hormonal secretion, and immunosenescence. The senescence of the immune system leads to improper control of infections and tissue damage increasing age-related diseases. One of the mechanisms that maintain cellular homeostasis is autophagy, a cell-survival mechanism, and it has been proposed as one of the most powerful antiaging therapies. Regular exercise can reestablish autophagy, probably through AMP-activated protein kinase activation, and help in reducing the age-related senescence diseases. Therefore, in this study, we discuss the effects of exercise training in immunosenescence and autophagy, preventing the two main age-related disease, cancer and neurodegeneration.




Citation Styles

Harvard Citation styleBatatinha, H., Diniz, T., de Souza Teixeira, A., Krüger, K. and Rosa-Neto, J. (2019) Regulation of autophagy as a therapy for immunosenescence-driven cancer and neurodegenerative diseases: The role of exercise, Journal of Cellular Physiology, 234(9), pp. 14883-14895. https://doi.org/10.1002/jcp.28318

APA Citation styleBatatinha, H., Diniz, T., de Souza Teixeira, A., Krüger, K., & Rosa-Neto, J. (2019). Regulation of autophagy as a therapy for immunosenescence-driven cancer and neurodegenerative diseases: The role of exercise. Journal of Cellular Physiology. 234(9), 14883-14895. https://doi.org/10.1002/jcp.28318


Last updated on 2025-21-05 at 17:10