Journal article

Publication year: 2016

Journal: Mediators of Inflammation

Volume number: 2016

ISSN: 0962-9351

eISSN: 1466-1861

Open access status: Gold

DOI Link: https://doi.org/10.1155/2016/4851935

Publisher: Wiley

Abstract: 

Acute physical exercise and repeated exercise stimuli affect whole-body metabolic and immunologic homeostasis. The aim of this study was to determine plasma protein profiles of trained (EET, n = 19) and untrained (SED, n = 17) individuals at rest and in response to an acute bout of endurance exercise. Participants completed a bicycle exercise test at an intensity corresponding to 80% of their VO2max. Plasma samples were taken before, directly after, and three hours after exercise and analyzed using multiplex immunoassays. Seventy-eight plasma variables were included in the final analysis. Twenty-nine variables displayed significant acute exercise effects in both groups. Seven proteins differed between groups, without being affected by acute exercise. Among these A2Macro and IL-5 were higher in EET individuals while leptin showed elevated levels in SED individuals. Fifteen variables revealed group and time differences with elevated levels for IL-3, IL-7, IL-10, and TNFR2 in EET individuals. An interaction effect could be observed for nine variables including IL-6, MMP-2, MMP-3, and muscle damage markers. The proteins that differ between groups indicate a long-term exercise effect on plasma protein concentrations. These findings might be of importance in the development of exercise-based strategies in the prevention and therapy of chronic metabolic and inflammatory diseases and for training monitoring.

Harvard Citation style: Schild, M., Eichner, G., Beiter, T., Zügel, M., Krumholz-Wagner, I., Hudemann, J., et al. (2016) Effects of Acute Endurance Exercise on Plasma Protein Profiles of Endurance-Trained and Untrained Individuals over Time, Mediators of Inflammation, 2016, Article 4851935. https://doi.org/10.1155/2016/4851935

APA Citation style: Schild, M., Eichner, G., Beiter, T., Zügel, M., Krumholz-Wagner, I., Hudemann, J., Pilat, C., Krüger, K., Niess, A., Steinacker, J., & Mooren, F. (2016). Effects of Acute Endurance Exercise on Plasma Protein Profiles of Endurance-Trained and Untrained Individuals over Time. Mediators of Inflammation. 2016, Article 4851935. https://doi.org/10.1155/2016/4851935