Journal article

Publication year: 2011

Pages: 281-284

Journal: Diabetes, Obesity and Metabolism: A Journal of Pharmacology and Therapeutics

Volume number: 13

Issue number: 3

ISSN: 1462-8902

DOI Link: https://doi.org/10.1111/j.1463-1326.2010.01332.x

Publisher: Wiley

Abstract: 

The incidence of insulin resistance and metabolic syndrome correlates with the availability of magnesium (Mg). We studied the effect of oral Mg supplementation on insulin sensitivity and other characteristics of the metabolic syndrome in normomagnesemic, overweight, insulin resistant, non-diabetic subjects. Subjects were tested for eligibility using oral glucose tolerance test (OGTT) and subsequently randomized to receive either Mg-aspartate-hydrochloride (n = 27) or placebo (n = 25) for 6 months. As trial endpoints, several indices of insulin sensitivity, plasma glucose, serum insulin, blood pressure and lipid profile were determined. Mg supplementation resulted in a significant improvement of fasting plasma glucose and some insulin sensitivity indices (ISIs) compared to placebo. Blood pressure and lipid profile did not show significant changes. The results provide significant evidence that oral Mg supplementation improves insulin sensitivity even in normomagnesemic, overweight, non-diabetic subjects emphasizing the need for an early optimization of Mg status to prevent insulin resistance and subsequently type 2 diabetes.

Harvard Citation style: Mooren, F., Krüger, K., Völker, K., Golf, S., Wadepuhl, M. and Kraus, A. (2011) Oral magnesium supplementation reduces insulin resistance in non-diabetic subjects - a double-blind, placebo-controlled, randomized trial, Diabetes, Obesity and Metabolism: A Journal of Pharmacology and Therapeutics, 13(3), pp. 281-284. https://doi.org/10.1111/j.1463-1326.2010.01332.x

APA Citation style: Mooren, F., Krüger, K., Völker, K., Golf, S., Wadepuhl, M., & Kraus, A. (2011). Oral magnesium supplementation reduces insulin resistance in non-diabetic subjects - a double-blind, placebo-controlled, randomized trial. Diabetes, Obesity and Metabolism: A Journal of Pharmacology and Therapeutics. 13(3), 281-284. https://doi.org/10.1111/j.1463-1326.2010.01332.x