Journal article

Publication year: 2023

Pages: 651-668

Journal: Journal of Integrative Agriculture

Volume number: 22

Issue number: 3

ISSN: 2095-3119

Open access status: Gold

DOI Link: https://doi.org/10.1016/j.jia.2022.11.003

Publisher: Elsevier

Abstract: 

Genetic control strategies such as the sterile insect technique have successfully fought insect pests worldwide. The CRISPR (clustered regularly interspaced short palindromic repeats) technology, together with high-quality genomic resources obtained in more and more species, greatly facilitates the development of novel genetic control insect strains that can be used in area-wide and species-specific pest control programs. Here, we review the research progress towards state-of-art CRISPR-based genetic control strategies, including gene drive, sex ratio distortion, CRISPR-engineered genetic sexing strains, and precision-guided sterile insect technique. These strategies' working mechanisms, potential resistance development mechanisms, and regulations are illustrated and discussed. In addition, recent developments such as stacked and conditional systems are introduced. We envision that the advances in genetic technology will continue to be one of the driving forces for developing the next generation of pest control strategies.

Harvard Citation style: Yan, Y., Aumann, R., Häcker, I. and Schetelig, M. (2023) CRISPR-based genetic control strategies for insect pests, Journal of Integrative Agriculture, 22(3), pp. 651-668. https://doi.org/10.1016/j.jia.2022.11.003

APA Citation style: Yan, Y., Aumann, R., Häcker, I., & Schetelig, M. (2023). CRISPR-based genetic control strategies for insect pests. Journal of Integrative Agriculture. 22(3), 651-668. https://doi.org/10.1016/j.jia.2022.11.003