Journalartikel

Jahr der Veröffentlichung: 2022

Zeitschrift: International Journal of Molecular Sciences

Bandnummer: 23

Heftnummer: 2

eISSN: 1422-0067

Open Access Status: Gold

DOI Link: https://doi.org/10.3390/ijms23020582

Verlag: MDPI

Abstract: 

After a long limbo, RNA has gained its credibility as a druggable target, fully earning its deserved role in the next generation of pharmaceutical R&D. We have recently probed the trans-activation response (TAR) element, an RNA stem–bulge–loop domain of the HIV-1 genome with bis-3-chloropiperidines (B-CePs), and revealed the compounds unique behavior in stabilizing TAR structure, thus impairing in vitro the chaperone activity of the HIV-1 nucleocapsid (NC) protein. Seeking to elucidate the determinants of B-CePs inhibition, we have further characterized here their effects on the target TAR and its NC recognition, while developing quantitative analytical approaches for the study of multicomponent RNA-based interactions.

Harvard-Zitierstil: Sosic, A., Olivato, G., Carraro, C., Göttlich, R., Fabris, D. and Gatto, B. (2022) In Vitro Evaluation of Bis-3-Chloropiperidines as RNA Modulators Targeting TAR and TAR-Protein Interaction, International Journal of Molecular Sciences, 23(2), Article 582. https://doi.org/10.3390/ijms23020582

APA-Zitierstil: Sosic, A., Olivato, G., Carraro, C., Göttlich, R., Fabris, D., & Gatto, B. (2022). In Vitro Evaluation of Bis-3-Chloropiperidines as RNA Modulators Targeting TAR and TAR-Protein Interaction. International Journal of Molecular Sciences. 23(2), Article 582. https://doi.org/10.3390/ijms23020582