Journal article

Autofocusing MALDI mass spectrometry imaging of tissue sections and 3D chemical topography of nonflat surfaces


Authors listKompauer, M; Heiles, S; Spengler, B

Publication year2017

Pages1156-1158

JournalNature Methods

Volume number14

Issue number12

ISSN1548-7091

DOI Linkhttps://doi.org/10.1038/nmeth.4433

PublisherNature Research


Abstract
We describe an atmospheric pressure matrix-assisted laser desorption-ionization mass spectrometry imaging system that uses long-distance laser triangulation on a micrometer scale to simultaneously obtain topographic and molecular information from 3D surfaces. We studied the topographic distribution of compounds on irregular 3D surfaces of plants and parasites, and we imaged nonplanar tissue sections with high lateral resolution, thereby eliminating height-related signal artifacts.



Citation Styles

Harvard Citation styleKompauer, M., Heiles, S. and Spengler, B. (2017) Autofocusing MALDI mass spectrometry imaging of tissue sections and 3D chemical topography of nonflat surfaces, Nature Methods, 14(12), pp. 1156-1158. https://doi.org/10.1038/nmeth.4433

APA Citation styleKompauer, M., Heiles, S., & Spengler, B. (2017). Autofocusing MALDI mass spectrometry imaging of tissue sections and 3D chemical topography of nonflat surfaces. Nature Methods. 14(12), 1156-1158. https://doi.org/10.1038/nmeth.4433


Last updated on 2025-21-05 at 13:21