Journal article

Determination of fluoroquinolones in chicken feces - A new liquid-liquid extraction method combined with LC-MS/MS


Authors listJanusch, F; Scherz, G; Mohring, SAI; Hamscher, G

Publication year2014

Pages792-799

JournalEnvironmental Toxicology and Pharmacology

Volume number38

Issue number3

ISSN1382-6689

DOI Linkhttps://doi.org/10.1016/j.etap.2014.09.011

PublisherElsevier


Abstract
The application of antibiotics including fluoroquinolones to farming animals is widespread and may lead to the development of antibiotic resistance and other environmental effects. To calculate environmental loads and for a proper risk assessment it is necessary to determine the antibiotic concentration in feces. Therefore, a new liquid-liquid extraction method combined with HPLC-MS/MS for the detection of marbofloxacin, ciprofloxacin, enrofloxacin and difloxacin in chicken feces was developed. Recoveries ranged from 51.0% to 83.5%. LOQs were between 0.10 and 1.09μg/kg. Feces of chickens treated with an enrofloxacin dosage of 10mg/kg bodyweight revealed maximum enrofloxacin and ciprofloxacin concentrations of 61.3 and 18.8mg/kg. Both antibiotics could be detected in feces up to two days after the last application in notable amounts (∼1mg/kg). Thus, feces of recently medicated chickens should not be used as a fertilizer without any further processing.



Citation Styles

Harvard Citation styleJanusch, F., Scherz, G., Mohring, S. and Hamscher, G. (2014) Determination of fluoroquinolones in chicken feces - A new liquid-liquid extraction method combined with LC-MS/MS, Environmental Toxicology and Pharmacology, 38(3), pp. 792-799. https://doi.org/10.1016/j.etap.2014.09.011

APA Citation styleJanusch, F., Scherz, G., Mohring, S., & Hamscher, G. (2014). Determination of fluoroquinolones in chicken feces - A new liquid-liquid extraction method combined with LC-MS/MS. Environmental Toxicology and Pharmacology. 38(3), 792-799. https://doi.org/10.1016/j.etap.2014.09.011


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