Journalartikel

Synthesis of the Antimalarial Drug FR900098 Utilizing the Nitroso-Ene Reaction


AutorenlisteFokin, AA; Yurchenko, AG; Rodionov, VN; Gunchenko, PA; Yurchenko, RI; Reichenberg, A; Wiesner, J; Hintz, M; Jomaa, H; Schreiner, PR

Jahr der Veröffentlichung2007

Seiten4379-4382

ZeitschriftOrganic Letters

Bandnummer9

Heftnummer21

ISSN1523-7060

DOI Linkhttps://doi.org/10.1021/ol702082k

VerlagAmerican Chemical Society


Abstract

The antimalarial drug FR900098 was prepared from diethyl
allylphosphonate involving the nitroso−ene reaction with nitrosocarbonyl
methane as the key step followed by hydrogenation and dealkylation. The
utilization of dibenzyl allylphosphonate as the starting compound
allows one-step hydrogenation with dealkylation, which simplifies the
preparative scheme further.




Zitierstile

Harvard-ZitierstilFokin, A., Yurchenko, A., Rodionov, V., Gunchenko, P., Yurchenko, R., Reichenberg, A., et al. (2007) Synthesis of the Antimalarial Drug FR900098 Utilizing the Nitroso-Ene Reaction, Organic Letters, 9(21), pp. 4379-4382. https://doi.org/10.1021/ol702082k

APA-ZitierstilFokin, A., Yurchenko, A., Rodionov, V., Gunchenko, P., Yurchenko, R., Reichenberg, A., Wiesner, J., Hintz, M., Jomaa, H., & Schreiner, P. (2007). Synthesis of the Antimalarial Drug FR900098 Utilizing the Nitroso-Ene Reaction. Organic Letters. 9(21), 4379-4382. https://doi.org/10.1021/ol702082k



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