Journal article

Synthesis of the Antimalarial Drug FR900098 Utilizing the Nitroso-Ene Reaction


Authors listFokin, AA; Yurchenko, AG; Rodionov, VN; Gunchenko, PA; Yurchenko, RI; Reichenberg, A; Wiesner, J; Hintz, M; Jomaa, H; Schreiner, PR

Publication year2007

Pages4379-4382

JournalOrganic Letters

Volume number9

Issue number21

ISSN1523-7060

DOI Linkhttps://doi.org/10.1021/ol702082k

PublisherAmerican Chemical Society


Abstract

The antimalarial drug FR900098 was prepared from diethyl
allylphosphonate involving the nitroso−ene reaction with nitrosocarbonyl
methane as the key step followed by hydrogenation and dealkylation. The
utilization of dibenzyl allylphosphonate as the starting compound
allows one-step hydrogenation with dealkylation, which simplifies the
preparative scheme further.




Citation Styles

Harvard Citation styleFokin, A., Yurchenko, A., Rodionov, V., Gunchenko, P., Yurchenko, R., Reichenberg, A., et al. (2007) Synthesis of the Antimalarial Drug FR900098 Utilizing the Nitroso-Ene Reaction, Organic Letters, 9(21), pp. 4379-4382. https://doi.org/10.1021/ol702082k

APA Citation styleFokin, A., Yurchenko, A., Rodionov, V., Gunchenko, P., Yurchenko, R., Reichenberg, A., Wiesner, J., Hintz, M., Jomaa, H., & Schreiner, P. (2007). Synthesis of the Antimalarial Drug FR900098 Utilizing the Nitroso-Ene Reaction. Organic Letters. 9(21), 4379-4382. https://doi.org/10.1021/ol702082k


Last updated on 2025-21-05 at 13:32