Meeting Abstract
Autorenliste: Spindler, Volker; Gerull, Brenda; Green, Kathleen J.; Kowalczyk, Andrew P.; Leube, Rudolf; Marian, Ali J.; Milting, Hendrik; Müller, Eliane J.; Niessen, Carien; Payne, Aimee S.; Schlegel, Nicolas; Schmidt, Enno; Strnad, Pavel; Tikkanen, Ritva; Vielmuth, Franziska; Waschke, Jens
Jahr der Veröffentlichung: 2023
Zeitschrift: Journal of Cell Science
Bandnummer: 136
Heftnummer: 1
ISSN: 0021-9533
eISSN: 1477-9137
Open Access Status: Bronze
DOI Link: https://doi.org/10.1242/jcs.260832
Konferenz: 1st Alpine desmosome disease meeting (ADDM)
Verlag: The Company of Biologists
Abstract:
Desmosome diseases are caused by dysfunction of desmosomes, which anchor intermediate filaments (IFs) at sites of cell-cell adhesion. For many decades, the focus of attention has been on the role of actin filament-associated adherens junctions in development and disease, especially cancer. However, interference with the function of desmosomes, their molecular constituents or their attachments to IFs has now emerged as a major contributor to a variety of diseases affecting different tissues and organs including skin, heart and the digestive tract. The first Alpine desmosome disease meeting (ADDM) held in Grainau, Germany, in October 2022 brought together international researchers from the basic sciences with clinical experts from diverse fields to share and discuss their ideas and concepts on desmosome function and dysfunction in the different cell types involved in desmosome diseases. Besides the prototypic desmosomal diseases pemphigus and arrhythmogenic cardiomyopathy, the role of desmosome dysfunction in inflammatory bowel diseases and eosinophilic was discussed.
Zitierstile
Harvard-Zitierstil: Spindler, V., Gerull, B., Green, K., Kowalczyk, A., Leube, R., Marian, A., et al. (2023) Meeting report - Desmosome dysfunction and disease: Alpine desmosome disease meeting, Journal of Cell Science, 136(1), Article jcs260832. https://doi.org/10.1242/jcs.260832
APA-Zitierstil: Spindler, V., Gerull, B., Green, K., Kowalczyk, A., Leube, R., Marian, A., Milting, H., Müller, E., Niessen, C., Payne, A., Schlegel, N., Schmidt, E., Strnad, P., Tikkanen, R., Vielmuth, F., & Waschke, J. (2023). Meeting report - Desmosome dysfunction and disease: Alpine desmosome disease meeting. Journal of Cell Science. 136(1), Article jcs260832. https://doi.org/10.1242/jcs.260832
Schlagwörter
CAUSES ARRHYTHMOGENIC CARDIOMYOPATHY
