Meeting Abstract

Meeting report - Desmosome dysfunction and disease: Alpine desmosome disease meeting


Authors listSpindler, Volker; Gerull, Brenda; Green, Kathleen J.; Kowalczyk, Andrew P.; Leube, Rudolf; Marian, Ali J.; Milting, Hendrik; Müller, Eliane J.; Niessen, Carien; Payne, Aimee S.; Schlegel, Nicolas; Schmidt, Enno; Strnad, Pavel; Tikkanen, Ritva; Vielmuth, Franziska; Waschke, Jens

Publication year2023

JournalJournal of Cell Science

Volume number136

Issue number1

ISSN0021-9533

eISSN1477-9137

Open access statusBronze

DOI Linkhttps://doi.org/10.1242/jcs.260832

Conference1st Alpine desmosome disease meeting (ADDM)

PublisherThe Company of Biologists


Abstract
Desmosome diseases are caused by dysfunction of desmosomes, which anchor intermediate filaments (IFs) at sites of cell-cell adhesion. For many decades, the focus of attention has been on the role of actin filament-associated adherens junctions in development and disease, especially cancer. However, interference with the function of desmosomes, their molecular constituents or their attachments to IFs has now emerged as a major contributor to a variety of diseases affecting different tissues and organs including skin, heart and the digestive tract. The first Alpine desmosome disease meeting (ADDM) held in Grainau, Germany, in October 2022 brought together international researchers from the basic sciences with clinical experts from diverse fields to share and discuss their ideas and concepts on desmosome function and dysfunction in the different cell types involved in desmosome diseases. Besides the prototypic desmosomal diseases pemphigus and arrhythmogenic cardiomyopathy, the role of desmosome dysfunction in inflammatory bowel diseases and eosinophilic was discussed.



Citation Styles

Harvard Citation styleSpindler, V., Gerull, B., Green, K., Kowalczyk, A., Leube, R., Marian, A., et al. (2023) Meeting report - Desmosome dysfunction and disease: Alpine desmosome disease meeting, Journal of Cell Science, 136(1), Article jcs260832. https://doi.org/10.1242/jcs.260832

APA Citation styleSpindler, V., Gerull, B., Green, K., Kowalczyk, A., Leube, R., Marian, A., Milting, H., Müller, E., Niessen, C., Payne, A., Schlegel, N., Schmidt, E., Strnad, P., Tikkanen, R., Vielmuth, F., & Waschke, J. (2023). Meeting report - Desmosome dysfunction and disease: Alpine desmosome disease meeting. Journal of Cell Science. 136(1), Article jcs260832. https://doi.org/10.1242/jcs.260832



Keywords


CAUSES ARRHYTHMOGENIC CARDIOMYOPATHY

Last updated on 2025-28-07 at 09:28