Journal article

Publication year: 2021

Journal: Cells

Volume number: 10

Issue number: 8

eISSN: 2073-4409

Open access status: Gold

DOI Link: https://doi.org/10.3390/cells10081982

Publisher: MDPI

Abstract: 
Schistosomiasis is one of the most prominent parasite-induced infectious diseases, causing tremendous medical and socioeconomic problems. Current studies have reported on the spread of endemic regions and the fear of development of resistance against praziquantel, the only effective drug available. Among the Schistosoma species, only S. haematobium is classified as a Group 1 carcinogen (definitely cancerogenic to humans), causing squamous cell carcinoma of the bladder, whereas infection with S. mansoni is included in Group 3 of carcinogenic hazards to humans by the International Agency for Research on Cancer (IARC), indicating insufficient evidence to determine its carcinogenicity. Nevertheless, although S. mansoni has not been discussed as an organic carcinogen, the multiplicity of case reports, together with recent data from animal models and cell culture experiments, suggests that this parasite can predispose patients to or promote hepatic and colorectal cancer. In this review, we discuss the current data, with a focus on new developments regarding the association of S. mansoni infection with human cancer and the recently discovered biomolecular mechanisms by which S. mansoni may predispose patients to cancer development and carcinogenesis.

Harvard Citation style: von Buelow, V., Lichtenberger, J., Grevelding, C., Falcone, F., Roeb, E. and Roderfeld, M. (2021) Does Schistosoma Mansoni Facilitate Carcinogenesis?, Cells, 10(8), Article 1982. https://doi.org/10.3390/cells10081982

APA Citation style: von Buelow, V., Lichtenberger, J., Grevelding, C., Falcone, F., Roeb, E., & Roderfeld, M. (2021). Does Schistosoma Mansoni Facilitate Carcinogenesis?. Cells. 10(8), Article 1982. https://doi.org/10.3390/cells10081982