Journalartikel
Autorenliste: Hahn, Luisa; Helmrich, Nora; Herebian, Diran; Mayatepek, Ertan; Drebber, Uta; Domann, Eugen; Olejniczak, Stefan; Weigel, Markus; Hain, Torsten; Rath, Timo; Wirtz, Stefan; Mollenkopf, Hans-Joachim; Schmidt, Nadine; Ewers, Christa; Baier, Anne; Churin, Yuri; Windhorst, Anita; Weiskirchen, Ralf; Steinhoff, Ulrich; Roeb, Elke; Roderfeld, Martin
Jahr der Veröffentlichung: 2020
Zeitschrift: Cells
Bandnummer: 9
Heftnummer: 9
eISSN: 2073-4409
Open Access Status: Gold
DOI Link: https://doi.org/10.3390/cells9091949
Verlag: MDPI
Abstract:
The Th2 cytokine IL-13 is involved in biliary epithelial injury and liver fibrosis in patients as well as in animal models. The aim of this study was to investigate IL-13 as a therapeutic target during short term and chronic intrahepatic cholestasis in anAbcb4-knockout mouse model (Abcb4(-/-)). Lack of IL-13 protectedAbcb4(-/-)mice transiently from cholestasis. This decrease in serum bile acids was accompanied by an enhanced excretion of bile acids and a normalization of fecal bile acid composition. InAbcb4(-/-)/IL-13(-/-)double knockout mice, bacterial translocation to the liver was significantly reduced and the intestinal microbiome resembled the commensal composition in wild type animals. In addition, 52-week-oldAbcb4(-/-)IL-13(-/-)mice showed significantly reduced hepatic fibrosis.Abcb4(-/-)mice devoid of IL-13 transiently improved cholestasis and converted the composition of the gut microbiota towards healthy conditions. This highlights IL-13 as a potential therapeutic target in biliary diseases.
Zitierstile
Harvard-Zitierstil: Hahn, L., Helmrich, N., Herebian, D., Mayatepek, E., Drebber, U., Domann, E., et al. (2020) IL-13 as Target to Reduce Cholestasis and Dysbiosis inAbcb4Knockout Mice, Cells, 9(9), Article 1949. https://doi.org/10.3390/cells9091949
APA-Zitierstil: Hahn, L., Helmrich, N., Herebian, D., Mayatepek, E., Drebber, U., Domann, E., Olejniczak, S., Weigel, M., Hain, T., Rath, T., Wirtz, S., Mollenkopf, H., Schmidt, N., Ewers, C., Baier, A., Churin, Y., Windhorst, A., Weiskirchen, R., Steinhoff, U., ...Roderfeld, M. (2020). IL-13 as Target to Reduce Cholestasis and Dysbiosis inAbcb4Knockout Mice. Cells. 9(9), Article 1949. https://doi.org/10.3390/cells9091949
Schlagwörter
BACTERIAL TRANSLOCATION; HEPATIC-FIBROSIS; INTERLEUKIN-13; intestinal microbiome; LIVER FIBROSIS; LIVER-INJURY; PRIMARY BILIARY-CIRRHOSIS; SCLEROSING CHOLANGITIS; Th2; TIGHT JUNCTION
