Journal article

IL-13 as Target to Reduce Cholestasis and Dysbiosis inAbcb4Knockout Mice


Authors listHahn, Luisa; Helmrich, Nora; Herebian, Diran; Mayatepek, Ertan; Drebber, Uta; Domann, Eugen; Olejniczak, Stefan; Weigel, Markus; Hain, Torsten; Rath, Timo; Wirtz, Stefan; Mollenkopf, Hans-Joachim; Schmidt, Nadine; Ewers, Christa; Baier, Anne; Churin, Yuri; Windhorst, Anita; Weiskirchen, Ralf; Steinhoff, Ulrich; Roeb, Elke; Roderfeld, Martin

Publication year2020

JournalCells

Volume number9

Issue number9

eISSN2073-4409

Open access statusGold

DOI Linkhttps://doi.org/10.3390/cells9091949

PublisherMDPI


Abstract
The Th2 cytokine IL-13 is involved in biliary epithelial injury and liver fibrosis in patients as well as in animal models. The aim of this study was to investigate IL-13 as a therapeutic target during short term and chronic intrahepatic cholestasis in anAbcb4-knockout mouse model (Abcb4(-/-)). Lack of IL-13 protectedAbcb4(-/-)mice transiently from cholestasis. This decrease in serum bile acids was accompanied by an enhanced excretion of bile acids and a normalization of fecal bile acid composition. InAbcb4(-/-)/IL-13(-/-)double knockout mice, bacterial translocation to the liver was significantly reduced and the intestinal microbiome resembled the commensal composition in wild type animals. In addition, 52-week-oldAbcb4(-/-)IL-13(-/-)mice showed significantly reduced hepatic fibrosis.Abcb4(-/-)mice devoid of IL-13 transiently improved cholestasis and converted the composition of the gut microbiota towards healthy conditions. This highlights IL-13 as a potential therapeutic target in biliary diseases.



Citation Styles

Harvard Citation styleHahn, L., Helmrich, N., Herebian, D., Mayatepek, E., Drebber, U., Domann, E., et al. (2020) IL-13 as Target to Reduce Cholestasis and Dysbiosis inAbcb4Knockout Mice, Cells, 9(9), Article 1949. https://doi.org/10.3390/cells9091949

APA Citation styleHahn, L., Helmrich, N., Herebian, D., Mayatepek, E., Drebber, U., Domann, E., Olejniczak, S., Weigel, M., Hain, T., Rath, T., Wirtz, S., Mollenkopf, H., Schmidt, N., Ewers, C., Baier, A., Churin, Y., Windhorst, A., Weiskirchen, R., Steinhoff, U., ...Roderfeld, M. (2020). IL-13 as Target to Reduce Cholestasis and Dysbiosis inAbcb4Knockout Mice. Cells. 9(9), Article 1949. https://doi.org/10.3390/cells9091949



Keywords


BACTERIAL TRANSLOCATIONHEPATIC-FIBROSISINTERLEUKIN-13intestinal microbiomeLIVER FIBROSISLIVER-INJURYPRIMARY BILIARY-CIRRHOSISSCLEROSING CHOLANGITISTh2TIGHT JUNCTION

Last updated on 2025-10-06 at 11:17