Journal article
Authors list: Tello, Khodr; Seeger, Werner; Naeije, Robert; Vanderpool, Rebecca; Ghofrani, Hossein Ardeschir; Richter, Manuel; Tedford, Ryan J.; Bogaard, Harm J.
Publication year: 2021
Pages: 90-107
Journal: British Journal of Pharmacology
Volume number: 178
Issue number: 1
ISSN: 0007-1188
eISSN: 1476-5381
Open access status: Bronze
DOI Link: https://doi.org/10.1111/bph.14866
Publisher: Wiley
Abstract:
Adaptation of right ventricular (RV) function to increased afterload-known as RV-arterial coupling-is a key determinant of prognosis in pulmonary hypertension. However, measurement of RV-arterial coupling is a complex, invasive process involving analysis of the RV pressure-volume relationship during preload reduction over multiple cardiac cycles. Simplified methods have therefore been proposed, including echocardiographic and cardiac MRI approaches. This review describes the available methods for assessment of RV function and RV-arterial coupling and the effects of pharmacotherapy on these variables. Overall, pharmacotherapies for pulmonary hypertension have shown beneficial effects on various measures of RV function, but it is often unclear if these are direct RV effects or indirect results of afterload reduction. Studies of the effects of pharmacotherapies on RV-arterial coupling are limited and mostly restricted to experimental models. Simplified methods to assess RV-arterial coupling should be validated and incorporated into routine clinical follow-up and future clinical trials.
Citation Styles
Harvard Citation style: Tello, K., Seeger, W., Naeije, R., Vanderpool, R., Ghofrani, H., Richter, M., et al. (2021) Right heart failure in pulmonary hypertension: Diagnosis and new perspectives on vascular and direct right ventricular treatment, British Journal of Pharmacology, 178(1), pp. 90-107. https://doi.org/10.1111/bph.14866
APA Citation style: Tello, K., Seeger, W., Naeije, R., Vanderpool, R., Ghofrani, H., Richter, M., Tedford, R., & Bogaard, H. (2021). Right heart failure in pulmonary hypertension: Diagnosis and new perspectives on vascular and direct right ventricular treatment. British Journal of Pharmacology. 178(1), 90-107. https://doi.org/10.1111/bph.14866
Keywords
ANGIOTENSIN-ALDOSTERONE SYSTEM; CONTRACTILE FUNCTION; DIASTOLIC STIFFNESS; EFFECTIVE ARTERIAL ELASTANCE; ENDOTHELIN-RECEPTOR ANTAGONIST; MYOCARDIAL FIBROSIS; PRESSURE-VOLUME RELATION; RHO-KINASE INHIBITOR; SINGLE-BEAT ESTIMATION
