Journalartikel

Resolvin E1 and its precursor 18R-HEPE restore mitochondrial function in inflammation


AutorenlisteHecker, Matthias; Sommer, Natascha; Foch, Sebastian; Hecker, Andreas; Hackstein, Holger; Witzenrath, Martin; Weissmann, Norbert; Seeger, Werner; Mayer, Konstantin

Jahr der Veröffentlichung2018

Seiten1016-1028

ZeitschriftBiochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Bandnummer1863

Heftnummer9

ISSN1388-1981

eISSN0006-3002

DOI Linkhttps://doi.org/10.1016/j.bbalip.2018.06.011

VerlagElsevier


Abstract
Inflammatory disorders such as sepsis are a major cause of morbidity and mortality. Mitochondrial dysfunction is considered a key factor in the pathogenesis of severe inflammation. In the present study, we aimed to investigate the impact of arachidonic acid, omega-3 (n-3) fatty acids, and n-3-derived lipid mediators 18R-HEPE and resolvin (Rv) E1 on mitochondrial function in experimental inflammation. The results revealed that, in contrast to n-6 and n-3 fatty acids, both 18R-HEPE and RvE1 possess anti-inflammatory and anti-apoptotic properties. Both mediators are able to restore inflammation-induced mitochondrial dysfunction, which is characterized by a decrease in mitochondrial respiration and membrane potential, as well as an imbalance of mitochondria] fission and fusion. Furthermore, inhibition of mitochondrial fission by Mdivi-1 and Dynasore reduces levels of the pro inflammatory cytokines IL-6 and IL-8. These results suggest a novel functional mechanism for the beneficial effects of RvE1 in inflammatory reactions.



Zitierstile

Harvard-ZitierstilHecker, M., Sommer, N., Foch, S., Hecker, A., Hackstein, H., Witzenrath, M., et al. (2018) Resolvin E1 and its precursor 18R-HEPE restore mitochondrial function in inflammation, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1863(9), pp. 1016-1028. https://doi.org/10.1016/j.bbalip.2018.06.011

APA-ZitierstilHecker, M., Sommer, N., Foch, S., Hecker, A., Hackstein, H., Witzenrath, M., Weissmann, N., Seeger, W., & Mayer, K. (2018). Resolvin E1 and its precursor 18R-HEPE restore mitochondrial function in inflammation. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1863(9), 1016-1028. https://doi.org/10.1016/j.bbalip.2018.06.011



Schlagwörter


FISSIONFUSIONPULMONARY ARTERIAL-HYPERTENSIONRANDOMIZED CONTROLLED-TRIALResolvinSEPTIC SHOCK


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