Journal article

Publication year: 2018

Pages: 1016-1028

Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Volume number: 1863

Issue number: 9

ISSN: 1388-1981

eISSN: 0006-3002

DOI Link: https://doi.org/10.1016/j.bbalip.2018.06.011

Publisher: Elsevier

Abstract: 
Inflammatory disorders such as sepsis are a major cause of morbidity and mortality. Mitochondrial dysfunction is considered a key factor in the pathogenesis of severe inflammation. In the present study, we aimed to investigate the impact of arachidonic acid, omega-3 (n-3) fatty acids, and n-3-derived lipid mediators 18R-HEPE and resolvin (Rv) E1 on mitochondrial function in experimental inflammation. The results revealed that, in contrast to n-6 and n-3 fatty acids, both 18R-HEPE and RvE1 possess anti-inflammatory and anti-apoptotic properties. Both mediators are able to restore inflammation-induced mitochondrial dysfunction, which is characterized by a decrease in mitochondrial respiration and membrane potential, as well as an imbalance of mitochondria] fission and fusion. Furthermore, inhibition of mitochondrial fission by Mdivi-1 and Dynasore reduces levels of the pro inflammatory cytokines IL-6 and IL-8. These results suggest a novel functional mechanism for the beneficial effects of RvE1 in inflammatory reactions.

Harvard Citation style: Hecker, M., Sommer, N., Foch, S., Hecker, A., Hackstein, H., Witzenrath, M., et al. (2018) Resolvin E1 and its precursor 18R-HEPE restore mitochondrial function in inflammation, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1863(9), pp. 1016-1028. https://doi.org/10.1016/j.bbalip.2018.06.011

APA Citation style: Hecker, M., Sommer, N., Foch, S., Hecker, A., Hackstein, H., Witzenrath, M., Weissmann, N., Seeger, W., & Mayer, K. (2018). Resolvin E1 and its precursor 18R-HEPE restore mitochondrial function in inflammation. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1863(9), 1016-1028. https://doi.org/10.1016/j.bbalip.2018.06.011