Sammelbandbeitrag

Erschienen in: ADVANCES IN VIRUS RESEARCH, VOL 96: CORONAVIRUSES

Herausgeberliste: Ziebuhr, J

Jahr der Veröffentlichung: 2016

Seiten: 127-163

Bandnummer: 96

ISSN: 0065-3527

eISSN: 1557-8399

eISBN: 978-0-12-804736-1

Open Access Status: Green

DOI Link: https://doi.org/10.1016/bs.aivir.2016.08.007

Serientitel: Advances in Virus Research

Abstract: 
Coronaviruses have exceptionally large RNA genomes of approximately 30 kilobases. Genome replication and transcription is mediated by a multisubunit protein complex comprised of more than a dozen virus-encoded proteins. The protein complex is thought to bind specific cis-acting RNA elements primarily located in the 50- and 30-terminal genome regions and upstream of the open reading frames located in the 30-proximal one-third of the genome. Here, we review our current understanding of coronavirus cis-acting RNA elements, focusing on elements required for genome replication and packaging. Recent bioinformatic, biochemical, and genetic studies suggest a previously unknown level of conservation of cis-acting RNA structures among different coronavirus genera and, in some cases, even beyond genus boundaries. Also, there is increasing evidence to suggest that individual cis-acting elements may be part of higher-order RNA structures involving long-range and dynamic RNA-RNA interactions between RNA structural elements separated by thousands of nucleotides in the viral genome. We discuss the structural and functional features of these cis-acting RNA elements and their specific functions in coronavirus RNA synthesis.

Harvard-Zitierstil: Madhugiri, R., Fricke, M., Marz, M. and Ziebuhr, J. (2016) Coronavirus cis-Acting RNA Elements, in Ziebuhr, J. (ed.) ADVANCES IN VIRUS RESEARCH, VOL 96: CORONAVIRUSES. ELSEVIER ACADEMIC PRESS INC, pp. 127-163. https://doi.org/10.1016/bs.aivir.2016.08.007

APA-Zitierstil: Madhugiri, R., Fricke, M., Marz, M., & Ziebuhr, J. (2016). Coronavirus cis-Acting RNA Elements. In Ziebuhr, J. (Ed.), ADVANCES IN VIRUS RESEARCH, VOL 96: CORONAVIRUSES (pp. 127-163). ELSEVIER ACADEMIC PRESS INC. https://doi.org/10.1016/bs.aivir.2016.08.007