Contribution in an anthology
Authors list: Madhugiri, R.; Fricke, M.; Marz, M.; Ziebuhr, J.
Appeared in: ADVANCES IN VIRUS RESEARCH, VOL 96: CORONAVIRUSES
Editor list: Ziebuhr, J
Publication year: 2016
Pages: 127-163
Volume number: 96
ISSN: 0065-3527
eISSN: 1557-8399
eISBN: 978-0-12-804736-1
Open access status: Green
DOI Link: https://doi.org/10.1016/bs.aivir.2016.08.007
Title of series: Advances in Virus Research
Abstract:
Coronaviruses have exceptionally large RNA genomes of approximately 30 kilobases. Genome replication and transcription is mediated by a multisubunit protein complex comprised of more than a dozen virus-encoded proteins. The protein complex is thought to bind specific cis-acting RNA elements primarily located in the 50- and 30-terminal genome regions and upstream of the open reading frames located in the 30-proximal one-third of the genome. Here, we review our current understanding of coronavirus cis-acting RNA elements, focusing on elements required for genome replication and packaging. Recent bioinformatic, biochemical, and genetic studies suggest a previously unknown level of conservation of cis-acting RNA structures among different coronavirus genera and, in some cases, even beyond genus boundaries. Also, there is increasing evidence to suggest that individual cis-acting elements may be part of higher-order RNA structures involving long-range and dynamic RNA-RNA interactions between RNA structural elements separated by thousands of nucleotides in the viral genome. We discuss the structural and functional features of these cis-acting RNA elements and their specific functions in coronavirus RNA synthesis.
Citation Styles
Harvard Citation style: Madhugiri, R., Fricke, M., Marz, M. and Ziebuhr, J. (2016) Coronavirus cis-Acting RNA Elements, in Ziebuhr, J. (ed.) ADVANCES IN VIRUS RESEARCH, VOL 96: CORONAVIRUSES. ELSEVIER ACADEMIC PRESS INC, pp. 127-163. https://doi.org/10.1016/bs.aivir.2016.08.007
APA Citation style: Madhugiri, R., Fricke, M., Marz, M., & Ziebuhr, J. (2016). Coronavirus cis-Acting RNA Elements. In Ziebuhr, J. (Ed.), ADVANCES IN VIRUS RESEARCH, VOL 96: CORONAVIRUSES (pp. 127-163). ELSEVIER ACADEMIC PRESS INC. https://doi.org/10.1016/bs.aivir.2016.08.007
Keywords
3' UNTRANSLATED REGION; DEFECTIVE INTERFERING RNA; LENGTH INFECTIOUS CDNA; PROTEIN-PROTEIN INTERACTIONS; PUTATIVE MOLECULAR SWITCH; REGULATORY SEQUENCE TRS; RESPIRATORY-SYNDROME CORONAVIRUS; RIBONUCLEOPROTEIN A1 BINDS
