Journal article

Publication year: 2014

Pages: 1189-1197

Journal: Andrologia

Volume number: 46

Issue number: 10

ISSN: 0303-4569

eISSN: 1439-0272

Open access status: Gold

DOI Link: https://doi.org/10.1111/and.12215

Publisher: Wiley

Abstract: 
As commonly used self-reported screening instruments for male hypogonadism demonstrated lack of specificity, a Hypogonadism Related Symptom Scale (HRS) was developed in 2009 as a novel self-rating screening tool. As the questionnaire has not been validated, the purpose of our study was to perform a validation in patients presenting with different disorders (e.g. infertility, HIV infection or metabolic syndrome) and disease-related risk to develop hypogonadism. Two hundred and eighteen patients aged 19-71years (40.1 +/- 9.5) who completed the HRS and other common questionnaires [International Index Of Erectile Function (IIEF), National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI), Hospital Anxiety and Depression Scale (HADS), short form (SF)-12] were included. In all patients, blood levels of total testosterone, luteinizing hormone, follicle-stimulating hormone, oestradiol and sex hormone-binding globulin were determined and free testosterone was calculated. Cronbach's for the scale was 0.896, split-half 0.871 for the 1st half and 0.807 for the 2nd half. Spearman-Brown coefficient was 0.767, and Guttman split-half coefficient was 0.759. Consistent correlations were found between HRS and IIEF5 (=0.57, P<0.001), and HADS (=-0.6, P<0.001). In addition, HRS was significantly correlated with total testosterone (=0.135, P<0.05), free testosterone (=0.148, P<0.05) and oestradiol (=-0.134, P<0.05). Our validation study confirms the data from the initial development of the HRS questionnaire. Clinicians might have an additional advantage from the HRS when investigating males with suspected hypogonadism.

Harvard Citation style: Alidjanov, J., Wolf, J., Schuppe, H., Weidner, W., Diemer, T., Linn, T., et al. (2014) Validation of the German version of the 'Hypogonadism Related Symptom Scale' (HRS) in andrological patients with infertility, HIV infection and metabolic syndrome, Andrologia, 46(10), pp. 1189-1197. https://doi.org/10.1111/and.12215

APA Citation style: Alidjanov, J., Wolf, J., Schuppe, H., Weidner, W., Diemer, T., Linn, T., Halefeldt, I., Wagenlehner, F., Wiltink, J., & Pilatz, A. (2014). Validation of the German version of the 'Hypogonadism Related Symptom Scale' (HRS) in andrological patients with infertility, HIV infection and metabolic syndrome. Andrologia. 46(10), 1189-1197. https://doi.org/10.1111/and.12215