Journalartikel

Jahr der Veröffentlichung: 2011

Seiten: 246-249

Zeitschrift: Zeitschrift für Geburtshilfe & Neonatologie

Bandnummer: 215

Heftnummer: 6

ISSN: 0948-2393

DOI Link: https://doi.org/10.1055/s-0031-1291215

Verlag: Georg Thieme Verlag

Abstract: 
Neonatal haemochromatosis (NH) is a connatal hepatopathy that is lethal in 32% and necessitates liver transplantation in 63% of the survivors. The classical diagnostic criteria of extrahepatic siderosis do not apply in all patients who are suspected to have NH. The hypothesis of NH as an alloimmune disease is supported by the quantitative immunohistochemical proof of C5b-9 complement complexes on the hepatocytes of liver biopsy material. This has opened a new perspective in the therapy and prophylaxis for this severe disease. Prophylactic therapy with intravenous immunoglobulins (IVIG) for mothers at risk can prevent a relevant NH in most cases.

Harvard-Zitierstil: Faas, D., Axt-Fliedner, R., Zimmer, K. and Heckmann, M. (2011) Prophylactic Prenatal Therapy with Intravenous Immunoglobulins for Patients at Risk for Neonatal Haemochromatosis, Zeitschrift für Geburtshilfe & Neonatologie, 215(6), pp. 246-249. https://doi.org/10.1055/s-0031-1291215

APA-Zitierstil: Faas, D., Axt-Fliedner, R., Zimmer, K., & Heckmann, M. (2011). Prophylactic Prenatal Therapy with Intravenous Immunoglobulins for Patients at Risk for Neonatal Haemochromatosis. Zeitschrift für Geburtshilfe & Neonatologie. 215(6), 246-249. https://doi.org/10.1055/s-0031-1291215