Journal article
Authors list: Faas, D.; Axt-Fliedner, R.; Zimmer, K. -P.; Heckmann, M.
Publication year: 2011
Pages: 246-249
Journal: Zeitschrift für Geburtshilfe & Neonatologie
Volume number: 215
Issue number: 6
ISSN: 0948-2393
DOI Link: https://doi.org/10.1055/s-0031-1291215
Publisher: Georg Thieme Verlag
Abstract:
Neonatal haemochromatosis (NH) is a connatal hepatopathy that is lethal in 32% and necessitates liver transplantation in 63% of the survivors. The classical diagnostic criteria of extrahepatic siderosis do not apply in all patients who are suspected to have NH. The hypothesis of NH as an alloimmune disease is supported by the quantitative immunohistochemical proof of C5b-9 complement complexes on the hepatocytes of liver biopsy material. This has opened a new perspective in the therapy and prophylaxis for this severe disease. Prophylactic therapy with intravenous immunoglobulins (IVIG) for mothers at risk can prevent a relevant NH in most cases.
Citation Styles
Harvard Citation style: Faas, D., Axt-Fliedner, R., Zimmer, K. and Heckmann, M. (2011) Prophylactic Prenatal Therapy with Intravenous Immunoglobulins for Patients at Risk for Neonatal Haemochromatosis, Zeitschrift für Geburtshilfe & Neonatologie, 215(6), pp. 246-249. https://doi.org/10.1055/s-0031-1291215
APA Citation style: Faas, D., Axt-Fliedner, R., Zimmer, K., & Heckmann, M. (2011). Prophylactic Prenatal Therapy with Intravenous Immunoglobulins for Patients at Risk for Neonatal Haemochromatosis. Zeitschrift für Geburtshilfe & Neonatologie. 215(6), 246-249. https://doi.org/10.1055/s-0031-1291215
Keywords
maternal intravenous immunoglobuline therapy; neonatal alloimmune disease; neonatal hemochromatosis
