Journalartikel
Autorenliste: Pavlovic, Sanja; Liezmann, Christiane; Blois, Sandra M.; Joachim, Ricarda; Kruse, Johannes; Romani, Nikolaus; Klapp, Burghard F.; Peters, Eva M. J.
Jahr der Veröffentlichung: 2011
Seiten: 848-855
Zeitschrift: The Journal of Immunology
Bandnummer: 186
Heftnummer: 2
ISSN: 0022-1767
eISSN: 1550-6606
DOI Link: https://doi.org/10.4049/jimmunol.0903878
Verlag: American Association of Immunologists
Abstract:
Interaction between the nervous and immune systems greatly contributes to inflammatory disease. In organs at the interface between our body and the environment, the sensory neuropeptide substance P (SP) is one key mediator of an acute local stress response through neurogenic inflammation but may also alter cytokine balance and dendritic cell (DC) function. Using a combined murine allergic inflammation/noise stress model with C57BL/6 mice, we show in this paper that SP-released during repeated stress exposure-has the capacity to markedly attenuate inflammation. In particular, repeated stress exposure prior to allergen sensitization increases DC-nerve fiber contacts, enhances DC migration and maturation, alters cytokine balance, and increases levels of IL-2 and T regulatory cell numbers in local lymph nodes and inflamed tissue in a neurokinin 1-SP-receptor (neurokinin-1 receptor)-dependent manner. Concordantly, allergic inflammation is significantly reduced after repeated stress exposure. We conclude that SP/repeated stress prior to immune activation acts protolerogenically and thereby beneficially in inflammation. The Journal of Immunology, 2011, 186: 848-855.
Zitierstile
Harvard-Zitierstil: Pavlovic, S., Liezmann, C., Blois, S., Joachim, R., Kruse, J., Romani, N., et al. (2011) Substance P Is a Key Mediator of Stress-Induced Protection from Allergic Sensitization via Modified Antigen Presentation, The Journal of Immunology, 186(2), pp. 848-855. https://doi.org/10.4049/jimmunol.0903878
APA-Zitierstil: Pavlovic, S., Liezmann, C., Blois, S., Joachim, R., Kruse, J., Romani, N., Klapp, B., & Peters, E. (2011). Substance P Is a Key Mediator of Stress-Induced Protection from Allergic Sensitization via Modified Antigen Presentation. The Journal of Immunology. 186(2), 848-855. https://doi.org/10.4049/jimmunol.0903878
Schlagwörter
ATOPIC-DERMATITIS; BRAIN-SKIN CONNECTION; CONTACT-DERMATITIS; GENE-RELATED PEPTIDE; INDUCED NEUROGENIC INFLAMMATION; Langerhans cells; MURINE SKIN; NERVE GROWTH-FACTOR; REGULATORY T-CELLS
