Journal article

Publication year: 2011

Pages: 848-855

Journal: The Journal of Immunology

Volume number: 186

Issue number: 2

ISSN: 0022-1767

eISSN: 1550-6606

DOI Link: https://doi.org/10.4049/jimmunol.0903878

Publisher: American Association of Immunologists

Abstract: 
Interaction between the nervous and immune systems greatly contributes to inflammatory disease. In organs at the interface between our body and the environment, the sensory neuropeptide substance P (SP) is one key mediator of an acute local stress response through neurogenic inflammation but may also alter cytokine balance and dendritic cell (DC) function. Using a combined murine allergic inflammation/noise stress model with C57BL/6 mice, we show in this paper that SP-released during repeated stress exposure-has the capacity to markedly attenuate inflammation. In particular, repeated stress exposure prior to allergen sensitization increases DC-nerve fiber contacts, enhances DC migration and maturation, alters cytokine balance, and increases levels of IL-2 and T regulatory cell numbers in local lymph nodes and inflamed tissue in a neurokinin 1-SP-receptor (neurokinin-1 receptor)-dependent manner. Concordantly, allergic inflammation is significantly reduced after repeated stress exposure. We conclude that SP/repeated stress prior to immune activation acts protolerogenically and thereby beneficially in inflammation. The Journal of Immunology, 2011, 186: 848-855.

Harvard Citation style: Pavlovic, S., Liezmann, C., Blois, S., Joachim, R., Kruse, J., Romani, N., et al. (2011) Substance P Is a Key Mediator of Stress-Induced Protection from Allergic Sensitization via Modified Antigen Presentation, The Journal of Immunology, 186(2), pp. 848-855. https://doi.org/10.4049/jimmunol.0903878

APA Citation style: Pavlovic, S., Liezmann, C., Blois, S., Joachim, R., Kruse, J., Romani, N., Klapp, B., & Peters, E. (2011). Substance P Is a Key Mediator of Stress-Induced Protection from Allergic Sensitization via Modified Antigen Presentation. The Journal of Immunology. 186(2), 848-855. https://doi.org/10.4049/jimmunol.0903878