Konferenzpaper
Autorenliste: Ghofrani, Hossein A.; Barst, Robyn J.; Benza, Raymond L.; Champion, Hunter C.; Fagan, Karen A.; Grimminger, Friedrich; Humbert, Marc; Simonneau, Gerald; Stewart, Duncan J.; Ventura, Carlo; Rubin, Lewis J.
Jahr der Veröffentlichung: 2009
Seiten: S108-S117
Zeitschrift: Journal of the American College of Cardiology
Bandnummer: 54
Heftnummer: 1
ISSN: 0735-1097
Open Access Status: Green
DOI Link: https://doi.org/10.1016/j.jacc.2009.04.014
Konferenz: 4th World Symposium on Pulmonary Hypertension
Verlag: Elsevier
Abstract:
Over the past 2 decades, pulmonary arterial hypertension has evolved from a uniformly fatal condition to a chronic, manageable disease in many cases, the result of unparalleled development of new therapies and advances in early diagnosis. However, none of the currently available therapies is curative, so the search for new treatment strategies continues. With a deeper understanding of the genetics and the molecular mechanisms of pulmonary vascular disorders, we are now at the threshold of entering a new therapeutic era. Our working group addressed what can be expected in the near future. The topics span the understanding of genetic variations, novel antiproliferative treatments, the role of stem cells, the right ventricle as a therapeutic target, and strategies and challenges for the translation of novel experimental findings into clinical practice. (J Am Coll Cardiol 2009;54:S108-17) (C) 2009 by the American College of Cardiology Foundation
Zitierstile
Harvard-Zitierstil: Ghofrani, H., Barst, R., Benza, R., Champion, H., Fagan, K., Grimminger, F., et al. (2009) Future Perspectives for the Treatment of Pulmonary Arterial Hypertension, Journal of the American College of Cardiology, 54(1), pp. S108-S117. https://doi.org/10.1016/j.jacc.2009.04.014
APA-Zitierstil: Ghofrani, H., Barst, R., Benza, R., Champion, H., Fagan, K., Grimminger, F., Humbert, M., Simonneau, G., Stewart, D., Ventura, C., & Rubin, L. (2009). Future Perspectives for the Treatment of Pulmonary Arterial Hypertension. Journal of the American College of Cardiology. 54(1), S108-S117. https://doi.org/10.1016/j.jacc.2009.04.014
Schlagwörter
ATRIAL-NATRIURETIC-PEPTIDE; CHRONIC HYPOXIA; ENDOTHELIAL GROWTH-FACTOR; GATED K+ CHANNELS; MYOCARDIAL-INFARCTION; NADPH OXIDASE; NITRIC-OXIDE SYNTHASE; PAH; PROTEIN-COUPLED RECEPTORS; pulmonary arterial hypertension; SMOOTH-MUSCLE-CELLS; TGF-BETA FAMILY