Conference paper

Future Perspectives for the Treatment of Pulmonary Arterial Hypertension


Authors listGhofrani, Hossein A.; Barst, Robyn J.; Benza, Raymond L.; Champion, Hunter C.; Fagan, Karen A.; Grimminger, Friedrich; Humbert, Marc; Simonneau, Gerald; Stewart, Duncan J.; Ventura, Carlo; Rubin, Lewis J.

Publication year2009

PagesS108-S117

JournalJournal of the American College of Cardiology

Volume number54

Issue number1

ISSN0735-1097

Open access statusGreen

DOI Linkhttps://doi.org/10.1016/j.jacc.2009.04.014

Conference4th World Symposium on Pulmonary Hypertension

PublisherElsevier


Abstract
Over the past 2 decades, pulmonary arterial hypertension has evolved from a uniformly fatal condition to a chronic, manageable disease in many cases, the result of unparalleled development of new therapies and advances in early diagnosis. However, none of the currently available therapies is curative, so the search for new treatment strategies continues. With a deeper understanding of the genetics and the molecular mechanisms of pulmonary vascular disorders, we are now at the threshold of entering a new therapeutic era. Our working group addressed what can be expected in the near future. The topics span the understanding of genetic variations, novel antiproliferative treatments, the role of stem cells, the right ventricle as a therapeutic target, and strategies and challenges for the translation of novel experimental findings into clinical practice. (J Am Coll Cardiol 2009;54:S108-17) (C) 2009 by the American College of Cardiology Foundation



Citation Styles

Harvard Citation styleGhofrani, H., Barst, R., Benza, R., Champion, H., Fagan, K., Grimminger, F., et al. (2009) Future Perspectives for the Treatment of Pulmonary Arterial Hypertension, Journal of the American College of Cardiology, 54(1), pp. S108-S117. https://doi.org/10.1016/j.jacc.2009.04.014

APA Citation styleGhofrani, H., Barst, R., Benza, R., Champion, H., Fagan, K., Grimminger, F., Humbert, M., Simonneau, G., Stewart, D., Ventura, C., & Rubin, L. (2009). Future Perspectives for the Treatment of Pulmonary Arterial Hypertension. Journal of the American College of Cardiology. 54(1), S108-S117. https://doi.org/10.1016/j.jacc.2009.04.014



Keywords


ATRIAL-NATRIURETIC-PEPTIDECHRONIC HYPOXIAENDOTHELIAL GROWTH-FACTORGATED K+ CHANNELSMYOCARDIAL-INFARCTIONNADPH OXIDASENITRIC-OXIDE SYNTHASEPAHPROTEIN-COUPLED RECEPTORSpulmonary arterial hypertensionSMOOTH-MUSCLE-CELLSTGF-BETA FAMILY

Last updated on 2025-10-06 at 09:50