Journalartikel

Exocrine pancreatic involvement in critically ill patients


AutorenlisteHardt, Philip D.; Mayer, Konstantin; Ewald, Nils

Jahr der Veröffentlichung2009

Seiten168-174

ZeitschriftCurrent Opinion in Clinical Nutrition and Metabolic Care

Bandnummer12

Heftnummer2

ISSN1363-1950

eISSN1473-6519

DOI Linkhttps://doi.org/10.1097/MCO.0b013e328322437e

VerlagLippincott, Williams & Wilkins


Abstract

Purpose of review

To learn about the prevalence, pathophysiology, and treatment of exocrine pancreatic involvement in critically ill patients.

Recent findings

Elevations in the levels of pancreatic enzymes are observed in up to 80% of intensive care patients. Most of these patients do not develop clinically relevant pancreatitis. However, elevations in enzyme levels do represent pancreatic damage with a risk of complications. Different factors have been discussed, which may contribute to pancreatic damage in critically ill patients. These include splanchnic hypoperfusion during shock or major surgery, bacterial translocation, elevated triglyceride levels, development of biliary sluge, and biliary pancreatitis, as well as several drugs. Imaging procedures and inflammatory markers help to identify relevant disease. Several therapeutic options have been discussed recently with a focus on early enteral nutrition.

Summary

Pancreatic damage is frequently observed in critically ill patients. Although in most of these patients, this is without major clinical consequences, some patients develop relevant pancreatitis, which contributes to morbidity and mortality. Risk factors have been identified and therapeutic strategies have been changed.




Zitierstile

Harvard-ZitierstilHardt, P., Mayer, K. and Ewald, N. (2009) Exocrine pancreatic involvement in critically ill patients, Current Opinion in Clinical Nutrition and Metabolic Care, 12(2), pp. 168-174. https://doi.org/10.1097/MCO.0b013e328322437e

APA-ZitierstilHardt, P., Mayer, K., & Ewald, N. (2009). Exocrine pancreatic involvement in critically ill patients. Current Opinion in Clinical Nutrition and Metabolic Care. 12(2), 168-174. https://doi.org/10.1097/MCO.0b013e328322437e



Schlagwörter


ACUTE BILIARY PANCREATITISBACTERIAL TRANSLOCATIONEARLY ENTERAL NUTRITIONENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHYexocrine pancreatic functionIntensive careINTENSIVE-CARE-UNITINTRACRANIAL EVENTSLIPASE ELEVATIONPARENTERAL-NUTRITIONRANDOMIZED CONTROLLED-TRIALSERUM AMYLASE


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