Journalartikel
Autorenliste: Skupin, Alexander; Kettenmann, Helmut; Winkler, Ulrike; Wartenberg, Maria; Sauer, Heinrich; Tovey, Stephen C.; Taylor, Colin W.; Falcke, Martin
Jahr der Veröffentlichung: 2008
Seiten: 2404-2411
Zeitschrift: Biophysical Journal
Bandnummer: 94
Heftnummer: 6
ISSN: 0006-3495
eISSN: 1542-0086
Open Access Status: Green
DOI Link: https://doi.org/10.1529/biophysj.107.119495
Verlag: Biophysical Society
Abstract:
Ca2+ oscillations have been considered to obey deterministic dynamics for almost two decades. We show for four cell types that Ca2+ oscillations are instead a sequence of random spikes. The standard deviation of the interspike intervals (ISIs) of individual spike trains is similar to the average ISI; it increases approximately linearly with the average ISI; and consecutive ISIs are uncorrelated. Decreasing the effective diffusion coefficient of free Ca2+ using Ca2+ buffers increases the average ISI and the standard deviation in agreement with the idea that individual spikes are caused by random wave nucleation. Array-enhanced coherence resonance leads to regular Ca2+ oscillations with small standard deviation of ISIs.
Zitierstile
Harvard-Zitierstil: Skupin, A., Kettenmann, H., Winkler, U., Wartenberg, M., Sauer, H., Tovey, S., et al. (2008) How does intracellular Ca2+ oscillate:: By chance or by the clock?, Biophysical Journal, 94(6), pp. 2404-2411. https://doi.org/10.1529/biophysj.107.119495
APA-Zitierstil: Skupin, A., Kettenmann, H., Winkler, U., Wartenberg, M., Sauer, H., Tovey, S., Taylor, C., & Falcke, M. (2008). How does intracellular Ca2+ oscillate:: By chance or by the clock?. Biophysical Journal. 94(6), 2404-2411. https://doi.org/10.1529/biophysj.107.119495
Schlagwörter
CALCIUM SIGNALS; CHANNEL CLUSTERS; ELEMENTARY EVENTS; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; IP3 RECEPTORS; PUFFS; TRISPHOSPHATE; WAVES
