Journal article

Publication year: 2008

Pages: 2404-2411

Journal: Biophysical Journal

Volume number: 94

Issue number: 6

ISSN: 0006-3495

eISSN: 1542-0086

Open access status: Green

DOI Link: https://doi.org/10.1529/biophysj.107.119495

Publisher: Biophysical Society

Abstract: 
Ca2+ oscillations have been considered to obey deterministic dynamics for almost two decades. We show for four cell types that Ca2+ oscillations are instead a sequence of random spikes. The standard deviation of the interspike intervals (ISIs) of individual spike trains is similar to the average ISI; it increases approximately linearly with the average ISI; and consecutive ISIs are uncorrelated. Decreasing the effective diffusion coefficient of free Ca2+ using Ca2+ buffers increases the average ISI and the standard deviation in agreement with the idea that individual spikes are caused by random wave nucleation. Array-enhanced coherence resonance leads to regular Ca2+ oscillations with small standard deviation of ISIs.

Harvard Citation style: Skupin, A., Kettenmann, H., Winkler, U., Wartenberg, M., Sauer, H., Tovey, S., et al. (2008) How does intracellular Ca²⁺ oscillate:: By chance or by the clock?, Biophysical Journal, 94(6), pp. 2404-2411. https://doi.org/10.1529/biophysj.107.119495

APA Citation style: Skupin, A., Kettenmann, H., Winkler, U., Wartenberg, M., Sauer, H., Tovey, S., Taylor, C., & Falcke, M. (2008). How does intracellular Ca²⁺ oscillate:: By chance or by the clock?. Biophysical Journal. 94(6), 2404-2411. https://doi.org/10.1529/biophysj.107.119495