Journalartikel

Jahr der Veröffentlichung: 2007

Seiten: 273-282

Zeitschrift: Transfusion and Apheresis Science

Bandnummer: 37

Heftnummer: 3

ISSN: 1473-0502

DOI Link: https://doi.org/10.1016/j.transci.2007.02.005

Verlag: Elsevier

Abstract: 
Transfusion-related acute lung injury (TRALI) is a serious, life-threatening complication of blood transfusion. Available evidence strongly suggests that leukocyte antibodies present in donor plasma are the predominant mechanism in TRALI. These antibodies lead to recipient neutrophil activation, with activated neutrophils inducing endothelial and alveolar damage in the lungs. These mechanisms are discussed in detail as are the alternative mechanisms that have been proposed. Preventive strategies that may help to reduce TRALI are presented. (C) 2007 Elsevier Ltd. All rights reserved.

Harvard-Zitierstil: Sachs, U. (2007) The pathogenesis of transfusion-related acute lung injury and how to avoid this serious adverse reaction of transfusion, Transfusion and Apheresis Science, 37(3), pp. 273-282. https://doi.org/10.1016/j.transci.2007.02.005

APA-Zitierstil: Sachs, U. (2007). The pathogenesis of transfusion-related acute lung injury and how to avoid this serious adverse reaction of transfusion. Transfusion and Apheresis Science. 37(3), 273-282. https://doi.org/10.1016/j.transci.2007.02.005