Journal article

Publication year: 2007

Pages: 273-282

Journal: Transfusion and Apheresis Science

Volume number: 37

Issue number: 3

ISSN: 1473-0502

DOI Link: https://doi.org/10.1016/j.transci.2007.02.005

Publisher: Elsevier

Abstract: 
Transfusion-related acute lung injury (TRALI) is a serious, life-threatening complication of blood transfusion. Available evidence strongly suggests that leukocyte antibodies present in donor plasma are the predominant mechanism in TRALI. These antibodies lead to recipient neutrophil activation, with activated neutrophils inducing endothelial and alveolar damage in the lungs. These mechanisms are discussed in detail as are the alternative mechanisms that have been proposed. Preventive strategies that may help to reduce TRALI are presented. (C) 2007 Elsevier Ltd. All rights reserved.

Harvard Citation style: Sachs, U. (2007) The pathogenesis of transfusion-related acute lung injury and how to avoid this serious adverse reaction of transfusion, Transfusion and Apheresis Science, 37(3), pp. 273-282. https://doi.org/10.1016/j.transci.2007.02.005

APA Citation style: Sachs, U. (2007). The pathogenesis of transfusion-related acute lung injury and how to avoid this serious adverse reaction of transfusion. Transfusion and Apheresis Science. 37(3), 273-282. https://doi.org/10.1016/j.transci.2007.02.005