Journalartikel

Jahr der Veröffentlichung: 2004

Seiten: 313-319

Zeitschrift: Amino Acids

Bandnummer: 27

Heftnummer: 3-4

ISSN: 0939-4451

eISSN: 1438-2199

DOI Link: https://doi.org/10.1007/s00726-004-0126-0

Verlag: Springer

Abstract: 
The objective of this study was to determine the effects of ornithine on polymorphonuclear leucocyte (PMN) free amino- and alpha-keto acid profiles, superoxide anion (O-2(-)) generation, hydrogen peroxide (H2O2) formation and released myeloperoxidase acitivity (MPO). Exogenous ornithine significantly increased PMN asparagine, glutamine, asparatate, glutamate, arginine, citrulline, alanine, alpha-ketoglutarate and pyruvate as intracellular ornithine increased. Concerning PMN immune function markers ornithine increased H2O2-generation and MPO acitivity while O-2(-)-formation was decreased. We believe therefore that ornithine is important for affecting PMN "susceptible free amino- and alpha-keto acid pool'' although the mechanisms are not yet clear. This may be one of the determinants in PMN nutrition considerably influencing and modulating PMN host defense capability.

Harvard-Zitierstil: Mühling, J., Fuchs, M., Campos, M., Gonter, J., Sablotzki, A., Engel, J., et al. (2004) Effects of ornithine on neutrophil (PMN) free amino acid and α-keto acid profiles and immune functions in vitro, Amino Acids, 27(3-4), pp. 313-319. https://doi.org/10.1007/s00726-004-0126-0

APA-Zitierstil: Mühling, J., Fuchs, M., Campos, M., Gonter, J., Sablotzki, A., Engel, J., Welters, I., Wolff, M., Matejec, R., Dehne, M., Menges, T., Krüll, M., & Hempelmann, G. (2004). Effects of ornithine on neutrophil (PMN) free amino acid and α-keto acid profiles and immune functions in vitro. Amino Acids. 27(3-4), 313-319. https://doi.org/10.1007/s00726-004-0126-0