Journal article

Publication year: 2004

Pages: 313-319

Journal: Amino Acids

Volume number: 27

Issue number: 3-4

ISSN: 0939-4451

eISSN: 1438-2199

DOI Link: https://doi.org/10.1007/s00726-004-0126-0

Publisher: Springer

Abstract: 
The objective of this study was to determine the effects of ornithine on polymorphonuclear leucocyte (PMN) free amino- and alpha-keto acid profiles, superoxide anion (O-2(-)) generation, hydrogen peroxide (H2O2) formation and released myeloperoxidase acitivity (MPO). Exogenous ornithine significantly increased PMN asparagine, glutamine, asparatate, glutamate, arginine, citrulline, alanine, alpha-ketoglutarate and pyruvate as intracellular ornithine increased. Concerning PMN immune function markers ornithine increased H2O2-generation and MPO acitivity while O-2(-)-formation was decreased. We believe therefore that ornithine is important for affecting PMN "susceptible free amino- and alpha-keto acid pool'' although the mechanisms are not yet clear. This may be one of the determinants in PMN nutrition considerably influencing and modulating PMN host defense capability.

Harvard Citation style: Mühling, J., Fuchs, M., Campos, M., Gonter, J., Sablotzki, A., Engel, J., et al. (2004) Effects of ornithine on neutrophil (PMN) free amino acid and α-keto acid profiles and immune functions in vitro, Amino Acids, 27(3-4), pp. 313-319. https://doi.org/10.1007/s00726-004-0126-0

APA Citation style: Mühling, J., Fuchs, M., Campos, M., Gonter, J., Sablotzki, A., Engel, J., Welters, I., Wolff, M., Matejec, R., Dehne, M., Menges, T., Krüll, M., & Hempelmann, G. (2004). Effects of ornithine on neutrophil (PMN) free amino acid and α-keto acid profiles and immune functions in vitro. Amino Acids. 27(3-4), 313-319. https://doi.org/10.1007/s00726-004-0126-0