Journalartikel

Jahr der Veröffentlichung: 2003

Seiten: 1443-1446

Zeitschrift: The Journal of Urology

Bandnummer: 170

Heftnummer: 4

ISSN: 0022-5347

eISSN: 1527-3792

DOI Link: https://doi.org/10.1097/01.ju.0000076488.89748.e1

Verlag: Lippincott, Williams & Wilkins

Abstract: 

Purpose: The pathogenesis of Peyronie's disease remains unclear. Previous studies have described possible associations among various HLAs and Peyronie's disease. However, only small series comprising 9 to 52 patients were analyzed in these studies and published results are controversial. We prospectively investigated a possible association of Peyronie's disease with HLA classes I and II specificity in a large patient group.

Materials and Methods: A total of 154 consecutive patients with Peyronie's disease were typed serologically for HLA class I antigens. Molecular typing of HLA class II alleles was performed by polymerase chain reaction sequence specific primers. Results were compared with those in healthy bone marrow donors for HLA classes I (2,450) and II (316), serving as representative controls selected from the local population. In addition, HLA distribution in a German normal cohort of 14,835 individuals served as a control.

Results: No significant difference in HLA classes I and II antigen frequency was evident in patients with Peyronie's disease compared with healthy controls.

Conclusions: The results of this study do not indicate any significant association between Peyronie's disease and antigens of the HLA system.

Harvard-Zitierstil: Hauck, E., Hauptmann, A., Weidner, W., Bein, G. and Hackstein, H. (2003) Prospective analysis of HLA classes I and II antigen frequency in patients with Peyronie's disease, The Journal of Urology, 170(4), pp. 1443-1446. https://doi.org/10.1097/01.ju.0000076488.89748.e1

APA-Zitierstil: Hauck, E., Hauptmann, A., Weidner, W., Bein, G., & Hackstein, H. (2003). Prospective analysis of HLA classes I and II antigen frequency in patients with Peyronie's disease. The Journal of Urology. 170(4), 1443-1446. https://doi.org/10.1097/01.ju.0000076488.89748.e1