Journalartikel

Jahr der Veröffentlichung: 1986

Seiten: 531-535

Zeitschrift: Naunyn-Schmiedeberg's Archives of Pharmacology

Bandnummer: 334

Heftnummer: 4

ISSN: 0028-1298

DOI Link: https://doi.org/10.1007/BF00569397

Verlag: Springer

Abstract: 
Paracetamol (5-15 mmol X l-1), phenacetin (1-3 mmol X l-1) and acetanilide (5-20 mmol X l-1) enhanced fluid, glucose and sodium absorption of isolated duodenal segments from rats. In a high concentration paracetamol (30 mmol X l-1) and acetanilide (25 mmol X l-1) inhibited these parameters. The coupling coefficient of 2:1 in sodium-glucose cotransport was not changed under the influence of the aniline derivatives. Phlorizin (10(-5) mol X l-1) completely abolished the stimulatory effect of these drugs. Also in presence of 3-O-methylglucose instead of glucose in the perfusion medium a paracetamol dependent increase in fluid absorption was seen, whereas the absorption of mannitol was unchanged. The results suggest, that the increase in sodium and fluid absorption caused by aniline derivatives is due to the stimulation of active glucose transport. A cytotoxic effect may explain the decrease of absorption at high concentrations of these substances.

Harvard-Zitierstil: Diener, M., Bridges, R. and Büch, H. (1986) The effect of aniline derivatives on absorption of fluid, glucose and sodium in isolated duodenal segments from rats, Naunyn-Schmiedeberg's Archives of Pharmacology, 334(4), pp. 531-535. https://doi.org/10.1007/BF00569397

APA-Zitierstil: Diener, M., Bridges, R., & Büch, H. (1986). The effect of aniline derivatives on absorption of fluid, glucose and sodium in isolated duodenal segments from rats. Naunyn-Schmiedeberg's Archives of Pharmacology. 334(4), 531-535. https://doi.org/10.1007/BF00569397