Journal article

Publication year: 1986

Pages: 531-535

Journal: Naunyn-Schmiedeberg's Archives of Pharmacology

Volume number: 334

Issue number: 4

ISSN: 0028-1298

DOI Link: https://doi.org/10.1007/BF00569397

Publisher: Springer

Abstract: 
Paracetamol (5-15 mmol X l-1), phenacetin (1-3 mmol X l-1) and acetanilide (5-20 mmol X l-1) enhanced fluid, glucose and sodium absorption of isolated duodenal segments from rats. In a high concentration paracetamol (30 mmol X l-1) and acetanilide (25 mmol X l-1) inhibited these parameters. The coupling coefficient of 2:1 in sodium-glucose cotransport was not changed under the influence of the aniline derivatives. Phlorizin (10(-5) mol X l-1) completely abolished the stimulatory effect of these drugs. Also in presence of 3-O-methylglucose instead of glucose in the perfusion medium a paracetamol dependent increase in fluid absorption was seen, whereas the absorption of mannitol was unchanged. The results suggest, that the increase in sodium and fluid absorption caused by aniline derivatives is due to the stimulation of active glucose transport. A cytotoxic effect may explain the decrease of absorption at high concentrations of these substances.

Harvard Citation style: Diener, M., Bridges, R. and Büch, H. (1986) The effect of aniline derivatives on absorption of fluid, glucose and sodium in isolated duodenal segments from rats, Naunyn-Schmiedeberg's Archives of Pharmacology, 334(4), pp. 531-535. https://doi.org/10.1007/BF00569397

APA Citation style: Diener, M., Bridges, R., & Büch, H. (1986). The effect of aniline derivatives on absorption of fluid, glucose and sodium in isolated duodenal segments from rats. Naunyn-Schmiedeberg's Archives of Pharmacology. 334(4), 531-535. https://doi.org/10.1007/BF00569397