Journalartikel

Jahr der Veröffentlichung: 2004

Seiten: 139-143

Zeitschrift: Neuroscience Letters

Bandnummer: 367

Heftnummer: 2

ISSN: 0304-3940

DOI Link: https://doi.org/10.1016/j.neulet.2004.04.053

Verlag: Elsevier

Abstract: 
Hyperforin, the major active constituent of St. John Wort (SJW) extract, affects several neurotransmitter systems in the brain putatively by modulation of the physical state of neuronal membranes. Accordingly, we tested the effects of SJW extract and of hyperforin on the properties of murine brain membrane fluidity. Oral administration of SJW extract and of hyperforin sodium salt results in significant hyperforin brain levels. Treatment of mice with hyperforin leads to decreased annular- and bulk fluidity and increased acyl-chain flexibility of brain membranes. All hyperforin related changs of membrane properties were significantly correlated with the corresponding hyperforin brain levels. Our data emphasises a membrane interaction of hyperforin that possibly contributes to its pharmacological effects.

Harvard-Zitierstil: Eckert, G., Keller, J., Jourdan, C., Karas, M., Volmer, D., Schubert-Zsilavecz, M., et al. (2004) Hyperforin modifies neuronal membrane properties in vivo, Neuroscience Letters, 367(2), pp. 139-143. https://doi.org/10.1016/j.neulet.2004.04.053

APA-Zitierstil: Eckert, G., Keller, J., Jourdan, C., Karas, M., Volmer, D., Schubert-Zsilavecz, M., & Müller, W. (2004). Hyperforin modifies neuronal membrane properties in vivo. Neuroscience Letters. 367(2), 139-143. https://doi.org/10.1016/j.neulet.2004.04.053