Journal article

Publication year: 2004

Pages: 139-143

Journal: Neuroscience Letters

Volume number: 367

Issue number: 2

ISSN: 0304-3940

DOI Link: https://doi.org/10.1016/j.neulet.2004.04.053

Publisher: Elsevier

Abstract: 
Hyperforin, the major active constituent of St. John Wort (SJW) extract, affects several neurotransmitter systems in the brain putatively by modulation of the physical state of neuronal membranes. Accordingly, we tested the effects of SJW extract and of hyperforin on the properties of murine brain membrane fluidity. Oral administration of SJW extract and of hyperforin sodium salt results in significant hyperforin brain levels. Treatment of mice with hyperforin leads to decreased annular- and bulk fluidity and increased acyl-chain flexibility of brain membranes. All hyperforin related changs of membrane properties were significantly correlated with the corresponding hyperforin brain levels. Our data emphasises a membrane interaction of hyperforin that possibly contributes to its pharmacological effects.

Harvard Citation style: Eckert, G., Keller, J., Jourdan, C., Karas, M., Volmer, D., Schubert-Zsilavecz, M., et al. (2004) Hyperforin modifies neuronal membrane properties in vivo, Neuroscience Letters, 367(2), pp. 139-143. https://doi.org/10.1016/j.neulet.2004.04.053

APA Citation style: Eckert, G., Keller, J., Jourdan, C., Karas, M., Volmer, D., Schubert-Zsilavecz, M., & Müller, W. (2004). Hyperforin modifies neuronal membrane properties in vivo. Neuroscience Letters. 367(2), 139-143. https://doi.org/10.1016/j.neulet.2004.04.053