Sammelbandbeitrag

Erschienen in: Apicomplexan Parasites: Molecular Approaches toward Targeted Drug Development

Herausgeberliste: Becker, K

Jahr der Veröffentlichung: 2011

Seiten: 307-318

ISBN: 978-3-527-63388-3

DOI Link: https://doi.org/10.1002/9783527633883.ch16

Serientitel: Drug discovery in infectious diseases

Serienzählung: 2

Abstract: 

Dehydrogenases and mitochondrial redox-associated processes are essentially involved in central energy metabolism of the apicomplexan parasites, including Plasmodium, Toxoplasma, Babesia, Eimeria, Cryptosporidium, Haemoproteus, and Neospora species. Despite the great potential of these enzymes and pathways to serve as target sites for novel antiparasitic control strategies, only a few of them have yet been characterized in detail. In this chapter, a review is provided of the current knowledge of mitochondrial enzymes of the electron transport chain and some dehydrogenases of the tricarboxylic acid (TCA) cycle of apicomplexan parasites, with respect to their function, structure, localization, and potential as drug targets.

Harvard-Zitierstil: Zocher, K., Rahlfs, S. and Becker, K. (2011) Dehydrogenases and enzyms of the mitochondrial electron transport chain as antiapicomplexan drug targets, in Becker, K. (ed.) Apicomplexan Parasites: Molecular Approaches toward Targeted Drug Development. Weinheim: John Wiley & Sons, Ltd, pp. 307-318. https://doi.org/10.1002/9783527633883.ch16

APA-Zitierstil: Zocher, K., Rahlfs, S., & Becker, K. (2011). Dehydrogenases and enzyms of the mitochondrial electron transport chain as antiapicomplexan drug targets. In Becker, K. (Ed.), Apicomplexan Parasites: Molecular Approaches toward Targeted Drug Development (pp. 307-318). John Wiley & Sons, Ltd. https://doi.org/10.1002/9783527633883.ch16