Contribution in an anthology

Appeared in: Apicomplexan Parasites: Molecular Approaches toward Targeted Drug Development

Editor list: Becker, K

Publication year: 2011

Pages: 307-318

ISBN: 978-3-527-63388-3

DOI Link: https://doi.org/10.1002/9783527633883.ch16

Title of series: Drug discovery in infectious diseases

Number in series: 2

Abstract: 

Dehydrogenases and mitochondrial redox-associated processes are essentially involved in central energy metabolism of the apicomplexan parasites, including Plasmodium, Toxoplasma, Babesia, Eimeria, Cryptosporidium, Haemoproteus, and Neospora species. Despite the great potential of these enzymes and pathways to serve as target sites for novel antiparasitic control strategies, only a few of them have yet been characterized in detail. In this chapter, a review is provided of the current knowledge of mitochondrial enzymes of the electron transport chain and some dehydrogenases of the tricarboxylic acid (TCA) cycle of apicomplexan parasites, with respect to their function, structure, localization, and potential as drug targets.

Harvard Citation style: Zocher, K., Rahlfs, S. and Becker, K. (2011) Dehydrogenases and enzyms of the mitochondrial electron transport chain as antiapicomplexan drug targets, in Becker, K. (ed.) Apicomplexan Parasites: Molecular Approaches toward Targeted Drug Development. Weinheim: John Wiley & Sons, Ltd, pp. 307-318. https://doi.org/10.1002/9783527633883.ch16

APA Citation style: Zocher, K., Rahlfs, S., & Becker, K. (2011). Dehydrogenases and enzyms of the mitochondrial electron transport chain as antiapicomplexan drug targets. In Becker, K. (Ed.), Apicomplexan Parasites: Molecular Approaches toward Targeted Drug Development (pp. 307-318). John Wiley & Sons, Ltd. https://doi.org/10.1002/9783527633883.ch16