Journalartikel

Jahr der Veröffentlichung: 1997

Seiten: 210-216

Zeitschrift: Nutrition, Metabolism & Cardiovascular Diseases

Bandnummer: 7

Heftnummer: 3

ISSN: 0939-4753

Verlag: Elsevier

Abstract: 
The findings that the beta-amyloid (beta A4) peptide possesses neurotoxic properties represents a possible link between beta A4 formation and neurodegeneration in Alzheimer's disease (AD). One possible mechanism of beta A4's neurotoxic properties in its direct effect on fluidity measures of mouse, rat, and human brain membranes, indicating that/beta A4 disturbs or even disrupts membrane structure and/or integrity. Altering membrane cholesterol not only directly affects calcium signalling of central neurons bur also modulates the effect of beta A4. It is suggested that changes of cholesterol distribution in the brain may represent one possible link between beta A4 induced neurodegeneration and Apolipoprotein E polymorphism as one of the genetic risk factors of AD.

Harvard-Zitierstil: Müller, W., Hartmann, H., Eckert, G., Eckert, A. and Eisert, S. (1997) Cholesterol affects neuronal calcium signalling. A possible link between apolipoprotein polymorphism, beta-amyloid neurotoxicity, and neurodegeneration in Alzheimer's disease, Nutrition, Metabolism & Cardiovascular Diseases, 7(3), pp. 210-216

APA-Zitierstil: Müller, W., Hartmann, H., Eckert, G., Eckert, A., & Eisert, S. (1997). Cholesterol affects neuronal calcium signalling. A possible link between apolipoprotein polymorphism, beta-amyloid neurotoxicity, and neurodegeneration in Alzheimer's disease. Nutrition, Metabolism & Cardiovascular Diseases. 7(3), 210-216.