Journal article
Authors list: Müller, WE; Hartmann, H; Eckert, GP; Eckert, A; Eisert, S
Publication year: 1997
Pages: 210-216
Journal: Nutrition, Metabolism & Cardiovascular Diseases
Volume number: 7
Issue number: 3
ISSN: 0939-4753
Publisher: Elsevier
Abstract:
The findings that the beta-amyloid (beta A4) peptide possesses neurotoxic properties represents a possible link between beta A4 formation and neurodegeneration in Alzheimer's disease (AD). One possible mechanism of beta A4's neurotoxic properties in its direct effect on fluidity measures of mouse, rat, and human brain membranes, indicating that/beta A4 disturbs or even disrupts membrane structure and/or integrity. Altering membrane cholesterol not only directly affects calcium signalling of central neurons bur also modulates the effect of beta A4. It is suggested that changes of cholesterol distribution in the brain may represent one possible link between beta A4 induced neurodegeneration and Apolipoprotein E polymorphism as one of the genetic risk factors of AD.
Citation Styles
Harvard Citation style: Müller, W., Hartmann, H., Eckert, G., Eckert, A. and Eisert, S. (1997) Cholesterol affects neuronal calcium signalling. A possible link between apolipoprotein polymorphism, beta-amyloid neurotoxicity, and neurodegeneration in Alzheimer's disease, Nutrition, Metabolism & Cardiovascular Diseases, 7(3), pp. 210-216
APA Citation style: Müller, W., Hartmann, H., Eckert, G., Eckert, A., & Eisert, S. (1997). Cholesterol affects neuronal calcium signalling. A possible link between apolipoprotein polymorphism, beta-amyloid neurotoxicity, and neurodegeneration in Alzheimer's disease. Nutrition, Metabolism & Cardiovascular Diseases. 7(3), 210-216.
