Phileucin - A Cyclic Dipeptide Similar to Phevalin (Aureusimine B) from Streptomyces coelicolor M1146 - Forschungsportal der Justus-Liebig-Universität Gießen:

Journalartikel

Phileucin - A Cyclic Dipeptide Similar to Phevalin (Aureusimine B) from Streptomyces coelicolor M1146

Autorenliste: Böhringer, N; Gütschow, M; König, GM; Schäberle, TF

Jahr der Veröffentlichung: 2017

Seiten: 107-109

Zeitschrift: Natural Product Communications

Bandnummer: 12

Heftnummer: 1

ISSN: 1934-578X

DOI Link: https://doi.org/10.1177/1934578X1701200131

Verlag: SAGE Publications

Abstract:
Overexpression of a putative type III polyketide synthase (PKSIII) from the marine myxobacterium Enhygromyxa sauna SWB007 in Streptomyces coelicolor M1146 led to the accumulation of a novel monoketopiperazine consisting of phenylalanine and isoleucine. This compound was named phileucin and shows high structural similarity to phevalin (aureusimine B). The protease inhibiting activity was tested against human cathepsin L, human leukocyte elastase, bovine trypsin and bovine chymotrypsin. In contrast to phevalin, no protease inhibition was observed.

Autoren/Herausgeber

- Uni.-Prof. Dr. Till Friedrich Schäberle

Zitierstile

Harvard-Zitierstil: Böhringer, N., Gütschow, M., König, G. and Schäberle, T. (2017) Phileucin - A Cyclic Dipeptide Similar to Phevalin (Aureusimine B) from Streptomyces coelicolor M1146, Natural Product Communications, 12(1), pp. 107-109. https://doi.org/10.1177/1934578X1701200131

APA-Zitierstil: Böhringer, N., Gütschow, M., König, G., & Schäberle, T. (2017). Phileucin - A Cyclic Dipeptide Similar to Phevalin (Aureusimine B) from Streptomyces coelicolor M1146. Natural Product Communications. 12(1), 107-109. https://doi.org/10.1177/1934578X1701200131