Journal article
Authors list: Böhringer, N; Gütschow, M; König, GM; Schäberle, TF
Publication year: 2017
Pages: 107-109
Journal: Natural Product Communications
Volume number: 12
Issue number: 1
ISSN: 1934-578X
DOI Link: https://doi.org/10.1177/1934578X1701200131
Publisher: SAGE Publications
Abstract:
Overexpression of a putative type III polyketide synthase (PKSIII) from the marine myxobacterium Enhygromyxa sauna SWB007 in Streptomyces coelicolor M1146 led to the accumulation of a novel monoketopiperazine consisting of phenylalanine and isoleucine. This compound was named phileucin and shows high structural similarity to phevalin (aureusimine B). The protease inhibiting activity was tested against human cathepsin L, human leukocyte elastase, bovine trypsin and bovine chymotrypsin. In contrast to phevalin, no protease inhibition was observed.
Citation Styles
Harvard Citation style: Böhringer, N., Gütschow, M., König, G. and Schäberle, T. (2017) Phileucin - A Cyclic Dipeptide Similar to Phevalin (Aureusimine B) from Streptomyces coelicolor M1146, Natural Product Communications, 12(1), pp. 107-109. https://doi.org/10.1177/1934578X1701200131
APA Citation style: Böhringer, N., Gütschow, M., König, G., & Schäberle, T. (2017). Phileucin - A Cyclic Dipeptide Similar to Phevalin (Aureusimine B) from Streptomyces coelicolor M1146. Natural Product Communications. 12(1), 107-109. https://doi.org/10.1177/1934578X1701200131