Journal article

Phileucin - A Cyclic Dipeptide Similar to Phevalin (Aureusimine B) from Streptomyces coelicolor M1146


Authors listBöhringer, N; Gütschow, M; König, GM; Schäberle, TF

Publication year2017

Pages107-109

JournalNatural Product Communications

Volume number12

Issue number1

ISSN1934-578X

DOI Linkhttps://doi.org/10.1177/1934578X1701200131

PublisherSAGE Publications


Abstract
Overexpression of a putative type III polyketide synthase (PKSIII) from the marine myxobacterium Enhygromyxa sauna SWB007 in Streptomyces coelicolor M1146 led to the accumulation of a novel monoketopiperazine consisting of phenylalanine and isoleucine. This compound was named phileucin and shows high structural similarity to phevalin (aureusimine B). The protease inhibiting activity was tested against human cathepsin L, human leukocyte elastase, bovine trypsin and bovine chymotrypsin. In contrast to phevalin, no protease inhibition was observed.



Citation Styles

Harvard Citation styleBöhringer, N., Gütschow, M., König, G. and Schäberle, T. (2017) Phileucin - A Cyclic Dipeptide Similar to Phevalin (Aureusimine B) from Streptomyces coelicolor M1146, Natural Product Communications, 12(1), pp. 107-109. https://doi.org/10.1177/1934578X1701200131

APA Citation styleBöhringer, N., Gütschow, M., König, G., & Schäberle, T. (2017). Phileucin - A Cyclic Dipeptide Similar to Phevalin (Aureusimine B) from Streptomyces coelicolor M1146. Natural Product Communications. 12(1), 107-109. https://doi.org/10.1177/1934578X1701200131


Last updated on 2025-21-05 at 16:19