Journal article

Publication year: 2016

Pages: 683-691

Journal: Chemistry in Life Sciences

Volume number: 349

Issue number: 9

ISSN: 0365-6233

DOI Link: https://doi.org/10.1002/ardp.201600064

Publisher: Wiley-VCH Verlag

Abstract: 
Microorganisms produce a vast array of biologically active metabolites. Such compounds are applied by humans to positively influence their health and, therefore, natural products serve as drug leads for pharmaceutical and medicinal chemistry. In this minireview, tools for the discovery and the production of potential drug leads are explained. A snapshot is provided, starting from the isolation of new producer strains, across genomic mining of (meta)genomes to identify biosynthetic gene clusters corresponding to natural products, toward heterologous expression to produce potential drug leads.

Harvard Citation style: Fisch, K. and Schäberle, T. (2016) Toolbox for Antibiotics Discovery from Microorganisms, Chemistry in Life Sciences, 349(9), pp. 683-691. https://doi.org/10.1002/ardp.201600064

APA Citation style: Fisch, K., & Schäberle, T. (2016). Toolbox for Antibiotics Discovery from Microorganisms. Chemistry in Life Sciences. 349(9), 683-691. https://doi.org/10.1002/ardp.201600064